ArticleNature communications2023
Pulcherriminic acid modulates iron availability and protects against oxidative stress during microbial interactions.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- A catechol-reactive Bacillus velezensis cell-free supernatant promotes Lentinula edodes mycelial growth and elicits an iron-homeostasis-related transcriptional response.World journal of microbiology & biotechnology · 2026Article
- Pulcherriminic acid as an antibiofilm effector: expandingJournal of bacteriology · 2026Review
- MeeY and YybP, two proteins regulated by manganese-sensing riboswitches, are required for Bacillus subtilis biofilm formation.NPJ biofilms and microbiomes · 2026Article
- Dopamine Is a Key Regulatory Molecule forMicroorganisms · 2026Article
- Mechanistic insights into the antimicrobial activity of a novel essential oil blend againstAIMS microbiology · 2026Article
- From Soil to Wine: Influence of Vegetative Covers on Microbial Communities and Fermentative Dynamics inMicroorganisms · 2025Article
- Characterization of Two Potential BiocontrolMicroorganisms · 2025Article
- A Tailored Artificial Biocatalyst for Bacterial Endophthalmitis Therapy via Enhanced Ferroptosis-Like Death.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Identification of widely conserved biosynthetic gene cluster involved in pigment production ofmSystems · 2025Article
- The iron chelator pulcherriminic acid mediates the light response in Bacillus subtilis biofilms.Nature communications · 2025Article
- Intraspecies warfare restricts strain coexistence in human skin microbiomes.Nature microbiology · 2025Article
- MitigatingBiofilm · 2025Article
- Intraspecies warfare restricts strain coexistence in human skin microbiomes.bioRxiv : the preprint server for biology · 2025Article
- Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament.Nature communications · 2025Article
- Significance of siderophore-producing cyanobacteria on enhancing iron uptake potentiality of maize plants grown under iron-deficiency.Microbial cell factories · 2025Article
- Pulcherriminic acid relay; aFrontiers in cellular and infection microbiology · 2025Review
- Pyoluteorin-deficient Pseudomonas protegens improves cooperation with Bacillus velezensis, biofilm formation, co-colonizing, and reshapes rhizosphere microbiome.NPJ biofilms and microbiomes · 2024Article
- Improving Beneficial Traits inPlants (Basel, Switzerland) · 2024Article
- High intragenomic, intergenomic, and phenotypic diversity in pulcherrimin-producing Metschnikowia yeasts indicates a special mode of genome evolution.Scientific reports · 2024Article
- Two distinct regulatory systems control pulcherrimin biosynthesis in Bacillus subtilis.PLoS genetics · 2024Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Siderophores are soluble or membrane-embedded molecules that bind the oxidized form of iron, Fe(III), and play roles in iron acquisition by microorganisms. Fe(III)-bound siderophores bind to specific receptors that allow microbes to acquire iron. However, certain soil microbes release a compound (pulcherriminic acid, PA) that, upon binding to Fe(III), forms a precipitate (pulcherrimin) that apparently functions by reducing iron availability rather than contributing to iron acquisition. Here, we use Bacillus subtilis (PA producer) and Pseudomonas protegens as a competition model to show that PA is involved in a peculiar iron-managing system. The presence of the competitor induces PA production, leading to precipitation of Fe(III) as pulcherrimin, which prevents oxidative stress in B. subtilis by restricting the Fenton reaction and deleterious ROS formation. In addition, B. subtilis uses its known siderophore bacillibactin to retrieve Fe(III) from pulcherrimin. Our findings indicate that PA plays multiple roles by modulating iron availability and conferring protection against oxidative stress during inter-species competition.
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