ArticleNeurology2023
Associations of CSF PDGFRβ With Aging, Blood-Brain Barrier Damage, Neuroinflammation, and Alzheimer Disease Pathologic Changes.
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In one paragraph
Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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37citing papers in PubMed, 2 pooled it
9.8field-weighted citation impact, top 1% of its field
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Differential detectability of pericyte and blood-brain barrier readouts across the Alzheimer's disease clinical continuum: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- Chitinase‑3 like‑protein‑1: A potential predictor of cardiovascular disease (Review).Molecular medicine reports · 2024Pooled it
- Dysregulated TIE-2 expression is associated with blood-brain barrier leakiness and Alzheimer's disease-related neuropathology.Brain pathology (Zurich, Switzerland) · 2026Article
- Biomarker Based ARIA Stress Test: A Proposed Conceptual Framework for Dynamic Biomarker-Guided ARIA Risk Stratification in Anti-Amyloid Immunotherapy for Alzheimer's Disease.Journal of molecular neuroscience : MN · 2026Review
- Plasma platelet-derived growth factor receptor-β decrease correlates with blood-brain barrier damage in Alzheimer's disease.Molecular neurodegeneration · 2026Article
- Serum and cerebrospinal fluid neuroinflammatory biomarkers and trimethylamine N-oxide: associations with white matter lesion severity.Frontiers in immunology · 2026Article
- Neurovascular Dysfunction and Glymphatic Impairment: An Unexplored Therapeutic Frontier in Neurodegeneration.International journal of molecular sciences · 2025Review
- CSF markers of vascular injury correlate with tau and cognitive decline in early Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Brain-derived neurotrophic factor supports pericyte and vascular homeostasis in the aging brain.Acta neuropathologica communications · 2025Article
- Mechanisms of high-density lipoprotein in regulating blood-brain barrier function: insights and implications.Fluids and barriers of the CNS · 2025Review
- Clinical effect of dexmedetomidine combined with landiolol hydrochloride on cerebral oxygen metabolism and inflammatory response in patients with severe craniocerebral injury.BMC anesthesiology · 2025Article
- Cerebrovascular disease in Alzheimer's disease: Brain structure as a critical mediator of cognitive decline.The journal of prevention of Alzheimer's disease · 2025Article
- Navigation Between Alzheimer's Disease (AD) and Its Various Pathophysiological Trajectories: The Pathogenic Link to Neuroimmunology-Genetics and Neuroinflammation.International journal of molecular sciences · 2025Review
- Disruption of the cerebrospinal fluid-plasma protein balance in cognitive impairment and aging.Nature medicine · 2025Article
- The blood-brain barrier: a help and a hindrance.Brain : a journal of neurology · 2025Review
- Cerebrospinal Fluid Biomarkers in Opioid Dependence: Evidence of Neuroimmune Activation and Ion Composition Changes, Without Alteration in Orexin-A.Addiction biology · 2025Article
- Biomarkers of blood-brain barrier and neurovascular unit integrity in human cognitive impairment and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Advances in the Study of Necroptosis in Vascular Dementia: Focus on Blood-Brain Barrier and Neuroinflammation.CNS neuroscience & therapeutics · 2025Review
- Vascular and metabolic responses to elevated circulating PDGF-BB in mice: A multiparametric MRI study.Health and metabolism · 2025Article
- Ion concentrations in CSF and serum are differentially and precisely regulated.Brain communications · 2025Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Claudia CicognolaFrom the Clinical Memory Research Unit (C.C., N.M.-C., S.P., K.A., O.S., E.S., S.J., O.H.), Department of Clinical Sciences, Lund University; Memory Clinic (C.C., S.P., E.S., O.H.), Skåne University Hospital, Malmö; Department of Neurology (N.M.-C.), Skåne University Hospital, Wallenberg Center for Molecular Medicine (N.M.-C.), and Department of Clinical Sciences Lund (D.v.W.), Diagnostic Radiology, Lund University; Imaging and Function (D.v.W.), Skåne University Health Care, Lund; Department of Psychiatry and Neurochemistry (H.Z., K.B.), the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; UK Dementia Research Institute at UCL (H.Z.), London, United Kingdom; Hong Kong Center for Neurodegenerative Diseases (H.Z.), Clear Water Bay, China; and Department of Neuropsychology (K.A.), Ruhr University Bochum, Germany. claudia.cicognola@med.lu.se.ORCID 0000-0003-1806-7089
Niklas Mattsson-CarlgrenFrom the Clinical Memory Research Unit (C.C., N.M.-C., S.P., K.A., O.S., E.S., S.J., O.H.), Department of Clinical Sciences, Lund University; Memory Clinic (C.C., S.P., E.S., O.H.), Skåne University Hospital, Malmö; Department of Neurology (N.M.-C.), Skåne University Hospital, Wallenberg Center for Molecular Medicine (N.M.-C.), and Department of Clinical Sciences Lund (D.v.W.), Diagnostic Radiology, Lund University; Imaging and Function (D.v.W.), Skåne University Health Care, Lund; Department of Psychiatry and Neurochemistry (H.Z., K.B.), the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; UK Dementia Research Institute at UCL (H.Z.), London, United Kingdom; Hong Kong Center for Neurodegenerative Diseases (H.Z.), Clear Water Bay, China; and Department of Neuropsychology (K.A.), Ruhr University Bochum, Germany.ORCID 0000-0002-8885-7724
Danielle van WestenFrom the Clinical Memory Research Unit (C.C., N.M.-C., S.P., K.A., O.S., E.S., S.J., O.H.), Department of Clinical Sciences, Lund University; Memory Clinic (C.C., S.P., E.S., O.H.), Skåne University Hospital, Malmö; Department of Neurology (N.M.-C.), Skåne University Hospital, Wallenberg Center for Molecular Medicine (N.M.-C.), and Department of Clinical Sciences Lund (D.v.W.), Diagnostic Radiology, Lund University; Imaging and Function (D.v.W.), Skåne University Health Care, Lund; Department of Psychiatry and Neurochemistry (H.Z., K.B.), the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; UK Dementia Research Institute at UCL (H.Z.), London, United Kingdom; Hong Kong Center for Neurodegenerative Diseases (H.Z.), Clear Water Bay, China; and Department of Neuropsychology (K.A.), Ruhr University Bochum, Germany.
Henrik ZetterbergFrom the Clinical Memory Research Unit (C.C., N.M.-C., S.P., K.A., O.S., E.S., S.J., O.H.), Department of Clinical Sciences, Lund University; Memory Clinic (C.C., S.P., E.S., O.H.), Skåne University Hospital, Malmö; Department of Neurology (N.M.-C.), Skåne University Hospital, Wallenberg Center for Molecular Medicine (N.M.-C.), and Department of Clinical Sciences Lund (D.v.W.), Diagnostic Radiology, Lund University; Imaging and Function (D.v.W.), Skåne University Health Care, Lund; Department of Psychiatry and Neurochemistry (H.Z., K.B.), the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; UK Dementia Research Institute at UCL (H.Z.), London, United Kingdom; Hong Kong Center for Neurodegenerative Diseases (H.Z.), Clear Water Bay, China; and Department of Neuropsychology (K.A.), Ruhr University Bochum, Germany.ORCID 0000-0002-4671-6763
Kaj BlennowFrom the Clinical Memory Research Unit (C.C., N.M.-C., S.P., K.A., O.S., E.S., S.J., O.H.), Department of Clinical Sciences, Lund University; Memory Clinic (C.C., S.P., E.S., O.H.), Skåne University Hospital, Malmö; Department of Neurology (N.M.-C.), Skåne University Hospital, Wallenberg Center for Molecular Medicine (N.M.-C.), and Department of Clinical Sciences Lund (D.v.W.), Diagnostic Radiology, Lund University; Imaging and Function (D.v.W.), Skåne University Health Care, Lund; Department of Psychiatry and Neurochemistry (H.Z., K.B.), the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; UK Dementia Research Institute at UCL (H.Z.), London, United Kingdom; Hong Kong Center for Neurodegenerative Diseases (H.Z.), Clear Water Bay, China; and Department of Neuropsychology (K.A.), Ruhr University Bochum, Germany.ORCID 0000-0002-1890-4193
Sebastian PalmqvistFrom the Clinical Memory Research Unit (C.C., N.M.-C., S.P., K.A., O.S., E.S., S.J., O.H.), Department of Clinical Sciences, Lund University; Memory Clinic (C.C., S.P., E.S., O.H.), Skåne University Hospital, Malmö; Department of Neurology (N.M.-C.), Skåne University Hospital, Wallenberg Center for Molecular Medicine (N.M.-C.), and Department of Clinical Sciences Lund (D.v.W.), Diagnostic Radiology, Lund University; Imaging and Function (D.v.W.), Skåne University Health Care, Lund; Department of Psychiatry and Neurochemistry (H.Z., K.B.), the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; UK Dementia Research Institute at UCL (H.Z.), London, United Kingdom; Hong Kong Center for Neurodegenerative Diseases (H.Z.), Clear Water Bay, China; and Department of Neuropsychology (K.A.), Ruhr University Bochum, Germany.
Khazar AhmadiFrom the Clinical Memory Research Unit (C.C., N.M.-C., S.P., K.A., O.S., E.S., S.J., O.H.), Department of Clinical Sciences, Lund University; Memory Clinic (C.C., S.P., E.S., O.H.), Skåne University Hospital, Malmö; Department of Neurology (N.M.-C.), Skåne University Hospital, Wallenberg Center for Molecular Medicine (N.M.-C.), and Department of Clinical Sciences Lund (D.v.W.), Diagnostic Radiology, Lund University; Imaging and Function (D.v.W.), Skåne University Health Care, Lund; Department of Psychiatry and Neurochemistry (H.Z., K.B.), the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; UK Dementia Research Institute at UCL (H.Z.), London, United Kingdom; Hong Kong Center for Neurodegenerative Diseases (H.Z.), Clear Water Bay, China; and Department of Neuropsychology (K.A.), Ruhr University Bochum, Germany.
Olof StrandbergFrom the Clinical Memory Research Unit (C.C., N.M.-C., S.P., K.A., O.S., E.S., S.J., O.H.), Department of Clinical Sciences, Lund University; Memory Clinic (C.C., S.P., E.S., O.H.), Skåne University Hospital, Malmö; Department of Neurology (N.M.-C.), Skåne University Hospital, Wallenberg Center for Molecular Medicine (N.M.-C.), and Department of Clinical Sciences Lund (D.v.W.), Diagnostic Radiology, Lund University; Imaging and Function (D.v.W.), Skåne University Health Care, Lund; Department of Psychiatry and Neurochemistry (H.Z., K.B.), the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; UK Dementia Research Institute at UCL (H.Z.), London, United Kingdom; Hong Kong Center for Neurodegenerative Diseases (H.Z.), Clear Water Bay, China; and Department of Neuropsychology (K.A.), Ruhr University Bochum, Germany.
Erik StomrudFrom the Clinical Memory Research Unit (C.C., N.M.-C., S.P., K.A., O.S., E.S., S.J., O.H.), Department of Clinical Sciences, Lund University; Memory Clinic (C.C., S.P., E.S., O.H.), Skåne University Hospital, Malmö; Department of Neurology (N.M.-C.), Skåne University Hospital, Wallenberg Center for Molecular Medicine (N.M.-C.), and Department of Clinical Sciences Lund (D.v.W.), Diagnostic Radiology, Lund University; Imaging and Function (D.v.W.), Skåne University Health Care, Lund; Department of Psychiatry and Neurochemistry (H.Z., K.B.), the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; UK Dementia Research Institute at UCL (H.Z.), London, United Kingdom; Hong Kong Center for Neurodegenerative Diseases (H.Z.), Clear Water Bay, China; and Department of Neuropsychology (K.A.), Ruhr University Bochum, Germany.
Shorena JanelidzeFrom the Clinical Memory Research Unit (C.C., N.M.-C., S.P., K.A., O.S., E.S., S.J., O.H.), Department of Clinical Sciences, Lund University; Memory Clinic (C.C., S.P., E.S., O.H.), Skåne University Hospital, Malmö; Department of Neurology (N.M.-C.), Skåne University Hospital, Wallenberg Center for Molecular Medicine (N.M.-C.), and Department of Clinical Sciences Lund (D.v.W.), Diagnostic Radiology, Lund University; Imaging and Function (D.v.W.), Skåne University Health Care, Lund; Department of Psychiatry and Neurochemistry (H.Z., K.B.), the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; UK Dementia Research Institute at UCL (H.Z.), London, United Kingdom; Hong Kong Center for Neurodegenerative Diseases (H.Z.), Clear Water Bay, China; and Department of Neuropsychology (K.A.), Ruhr University Bochum, Germany.
Oskar HanssonFrom the Clinical Memory Research Unit (C.C., N.M.-C., S.P., K.A., O.S., E.S., S.J., O.H.), Department of Clinical Sciences, Lund University; Memory Clinic (C.C., S.P., E.S., O.H.), Skåne University Hospital, Malmö; Department of Neurology (N.M.-C.), Skåne University Hospital, Wallenberg Center for Molecular Medicine (N.M.-C.), and Department of Clinical Sciences Lund (D.v.W.), Diagnostic Radiology, Lund University; Imaging and Function (D.v.W.), Skåne University Health Care, Lund; Department of Psychiatry and Neurochemistry (H.Z., K.B.), the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology; UK Dementia Research Institute at UCL (H.Z.), London, United Kingdom; Hong Kong Center for Neurodegenerative Diseases (H.Z.), Clear Water Bay, China; and Department of Neuropsychology (K.A.), Ruhr University Bochum, Germany.
Skåne University Hospital · SELund University · SEUK Dementia Research Institute · GB
Funding
The effects of iron on oxidative stress and Alzheimer's biomarkers in amyloid-positive and negative elderly normalR01AG068398 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHIANG, GLORIA CHIA-YI · 2020 to 2024
$2.8MNIA NIH HHS R01 AG068398
Abstract
BACKGROUND AND
objectivesInjured pericytes in the neurovascular unit release platelet-derived growth factor β (PDGFRβ) into the CSF. However, it is not clear how pericyte injury contributes to Alzheimer disease (AD)-related changes and blood-brain barrier (BBB) damage. We aimed to test whether CSF PDGFRβ was associated with different AD-associated and age-associated pathologic changes leading to dementia.
methodsPDGFRβ was measured in the CSF of 771 participants with cognitively unimpaired (CU, n = 408), mild cognitive impairment (MCI, n = 175), and dementia (n = 188) from the Swedish BioFINDER-2 cohort. We then checked association with β-amyloid (Aβ)-PET and tau-PET standardized uptake value ratio,
resultsThe cohort had a mean age of 67 years (CU = 62.8, MCI = 69.9, dementia = 70.4), and 50.1% were male (CU = 46.6%, MCI = 53.7%, dementia = 54.3%). Higher CSF PDGFRβ concentrations were related to higher age ( DISCUSSION: In summary, pericyte damage, reflected by CSF PDGFRβ, may be involved in age-related BBB disruption together with neuroinflammation, but is not related to Alzheimer-related pathologic changes.
Indexed as
Alzheimer DiseaseCognitive DysfunctionVascular DiseasesAgedAgingAmyloid beta-PeptidesApolipoprotein E4BiomarkersBlood-Brain BarrierChitinase-3-Like Protein 1FemaleHumansMaleNeuroinflammatory Diseasestau ProteinsAmyloid beta-PeptidesApolipoprotein E4BiomarkersChitinase-3-Like Protein 1tau Proteins
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