Evidence map›Paper›PMID 37137719›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2023

Representative Rodent Models for Renal Transporter Alterations in Human Nonalcoholic Steatohepatitis.

Kayla L Frost, Joseph L Jilek, Erica L Toth, Michael J Goedken, Stephen H Wright, Nathan J Cherrington

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kayla L FrostCollege of Pharmacy, Department of Pharmacology & Toxicology (K.L.F., J.L.J., E.L.T., N.J.C.) and College of Medicine, Department of Physiology (S.H.W.), The University of Arizona, Tucson, Arizona and Department of Pharmacology & Toxicology, Rutgers University, Piscataway, New Jersey (M.J.G.).
Joseph L JilekCollege of Pharmacy, Department of Pharmacology & Toxicology (K.L.F., J.L.J., E.L.T., N.J.C.) and College of Medicine, Department of Physiology (S.H.W.), The University of Arizona, Tucson, Arizona and Department of Pharmacology & Toxicology, Rutgers University, Piscataway, New Jersey (M.J.G.).ORCID 0000-0003-4215-9434
Erica L TothCollege of Pharmacy, Department of Pharmacology & Toxicology (K.L.F., J.L.J., E.L.T., N.J.C.) and College of Medicine, Department of Physiology (S.H.W.), The University of Arizona, Tucson, Arizona and Department of Pharmacology & Toxicology, Rutgers University, Piscataway, New Jersey (M.J.G.).
Michael J GoedkenCollege of Pharmacy, Department of Pharmacology & Toxicology (K.L.F., J.L.J., E.L.T., N.J.C.) and College of Medicine, Department of Physiology (S.H.W.), The University of Arizona, Tucson, Arizona and Department of Pharmacology & Toxicology, Rutgers University, Piscataway, New Jersey (M.J.G.).
Stephen H WrightCollege of Pharmacy, Department of Pharmacology & Toxicology (K.L.F., J.L.J., E.L.T., N.J.C.) and College of Medicine, Department of Physiology (S.H.W.), The University of Arizona, Tucson, Arizona and Department of Pharmacology & Toxicology, Rutgers University, Piscataway, New Jersey (M.J.G.).
Nathan J CherringtonCollege of Pharmacy, Department of Pharmacology & Toxicology (K.L.F., J.L.J., E.L.T., N.J.C.) and College of Medicine, Department of Physiology (S.H.W.), The University of Arizona, Tucson, Arizona and Department of Pharmacology & Toxicology, Rutgers University, Piscataway, New Jersey (M.J.G.) cherring@pharmacy.arizona.edu.
University of Arizona · USRutgers, The State University of New Jersey · US

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
Renal Disposition in NASHR01ES028668 · NIEHS · UNIVERSITY OF ARIZONA · PI CHERRINGTON, NATHAN J · 2019 to 2023
$2.4M
NIEHS NIH HHS P30 ES006694NIEHS NIH HHS R01 ES028668
6 · The paper itself

Abstract

Alterations in renal elimination processes of glomerular filtration and active tubular secretion by renal transporters can result in adverse drug reactions. Nonalcoholic steatohepatitis (NASH) alters hepatic transporter expression and xenobiotic elimination, but until recently, renal transporter alterations in NASH were unknown. This study investigates renal transporter changes in rodent models of NASH to identify a model that recapitulates human alterations. Quantitative protein expression by surrogate peptide liquid chromatography-coupled mass spectrometry (LC-MS/MS) on renal biopsies from NASH patients was used for concordance analysis with rodent models, including methionine/choline deficient (MCD), atherogenic (Athero), or control rats and

Indexed as

Non-alcoholic Fatty Liver DiseaseAnimalsCholineChromatography, LiquidDisease Models, AnimalHumansLiverMembrane Transport ProteinsMethionineMiceMice, Inbred C57BLObesityRatsRodentiaTandem Mass SpectrometryCholineMembrane Transport ProteinsMethionine

Identifiers

PMID37137719
PMCPMC10353148
OpenAlexW4367836595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.