ArticleThe American journal of clinical nutrition2023
Estimating the serum folate concentration that corresponds to the red blood cell folate concentration threshold associated with optimal neural tube defects prevention: A population-based biomarker survey in Southern India.
Article in The American journal of clinical nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04048330 (Periconceptional Surveillance for Prevention of Anemia and Birth Defects in India), which is not on this map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Periconceptional Surveillance for Prevention of Anemia and Birth Defects in India
Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- A Randomized Crossover Trial of Acceptability of Quadruple-Fortified Salt in Women and their Households in Southern India.The Journal of nutrition · 2025Trial
- Serum Concentrations of Folate Forms Following Supplementation of Multimicronutrients with 400 µg or 800 µg Mix of (6S)-5-Methyltetrahydrofolate and Folic Acid (1:1) in Women of Childbearing Age.Molecular nutrition & food research · 2024Trial
- Trial
- Associations between Red Blood Cell Folate Forms and Demographic, Physiologic, and Lifestyle Factors in the United States Population: Cross-Sectional Data from the National Health and Nutrition Examination Survey August 2021-August 2023.Current developments in nutrition · 2026Article
- Prior Pregnancies Deplete Maternal Folate Status and Increase Risks of Neural Tube Defects in Addis Ababa, Ethiopia.The Journal of nutrition · 2026Article
- Dietary Vitamin B-9 and B-12 Deficiencies Alter Gut Homeostasis in Sprague-Dawley Rats.The Journal of nutrition · 2026Article
- Red blood cell folate and depression risk in U.S. women: A dose-response analysis from a nationwide cross-sectional study (2009-2018).Medicine · 2026Article
- Prediabetes, diabetes, and folate status among United States women of reproductive age: NHANES 2011-March 2020.The American journal of clinical nutrition · 2026Article
- Congenital heart disease and folate pathway gene polymorphisms: findings from a North Indian cohort.BMC cardiovascular disorders · 2026Article
- Folate status shows no relationship with vitamin B12 but reiterates the urgency for folate fortification in the UK.European journal of nutrition · 2025Article
- Vitamin BClinical nutrition ESPEN · 2025Observational
- Impaired folate status in patients with mental disorders.Acta neuropsychiatrica · 2025Article
- Pharmacokinetics of (6S)-5-Methyltetrahydrofolate dicholine salt compared to folic acid: a randomized double-blind single dose cross-over study.Food & nutrition research · 2025Article
- Mass spectrometry of water-soluble vitamins to establish a risk model for predicting recurrent spontaneous abortion.Scientific reports · 2024Article
- Folate and Vitamin B12 Status in Women of Reproductive Age in Rural Haryana, India: Estimating Population-Based Prevalence for Neural Tube Defects.Birth defects research · 2024Article
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14 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundRBC folate concentrations are monitored at the population level, with a recommended threshold for optimal neural tube defect (NTD) prevention. A corresponding threshold for serum folate has not been established.
objectivesThis study aimed to estimate the serum folate insufficiency threshold corresponding to the RBC folate threshold for NTD prevention and examine how this threshold is modified by vitamin B
methodsParticipants were women (15-40 y; not pregnant or lactating; n = 977) from a population-based biomarker survey in Southern India. RBC folate and serum folate were measured via microbiologic assay. RBC folate deficiency (<305 nmol/L) and insufficiency (<748 nmol/L), serum vitamin B
resultsCompared with adequate vitamin B
conclusionsThe estimated serum folate threshold for optimal NTD prevention was similar to previous reports (24.3 vs. 25.6 nmol/L) among participants with sufficient vitamin B
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