Evidence map›Paper›PMID 37137343›Full record

ArticleFree radical biology & medicine2023

Pharmacological ascorbate induces sustained mitochondrial dysfunction.

Rory S Carroll, Juan Du, Brianne R O'Leary, Garett Steers, Prabhat C Goswami, Garry R Buettner, Joseph J Cullen

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06493370 (Intravenous Ascorbate Plus Gemcitabine/Carboplatin), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06493370 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Intravenous Ascorbate Plus Gemcitabine/Carboplatin: A Novel and Cost-Effective Alternative With Evident Efficacy in Patients With Muscle Invasive Bladder Cancer

TypeinterventionalSponsorUniversity of Kansas Medical CenterRan2025 to 2030Enrolled48ConditionsBladder CancerArmsIntravenous ascorbic acid/vitamin C
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rory S CarrollDepartments of Surgery, University of Iowa College of Medicine, USA.
Juan DuDepartments of Surgery, University of Iowa College of Medicine, USA; Free Radical and Radiation Biology Program, University of Iowa College of Medicine, USA.
Brianne R O'LearyDepartments of Surgery, University of Iowa College of Medicine, USA; Free Radical and Radiation Biology Program, University of Iowa College of Medicine, USA.
Garett SteersDepartments of Surgery, University of Iowa College of Medicine, USA.
Prabhat C GoswamiFree Radical and Radiation Biology Program, University of Iowa College of Medicine, USA; Radiation Oncology, University of Iowa College of Medicine, USA; Holden Comprehensive Cancer Center, University of Iowa College of Medicine, USA.
Garry R BuettnerFree Radical and Radiation Biology Program, University of Iowa College of Medicine, USA; Radiation Oncology, University of Iowa College of Medicine, USA; Holden Comprehensive Cancer Center, University of Iowa College of Medicine, USA.
Joseph J CullenDepartments of Surgery, University of Iowa College of Medicine, USA; Free Radical and Radiation Biology Program, University of Iowa College of Medicine, USA; Radiation Oncology, University of Iowa College of Medicine, USA; Holden Comprehensive Cancer Center, University of Iowa College of Medicine, USA. Electronic address: joseph-cullen@uiowa.edu.
University of Iowa · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5M
Health Promotion and Disease Prevention Research CenterU48DP006377 · DP · EMORY UNIVERSITY · PI KEGLER, MICHELLE C · 2018 to 2023
$13.5M
Project 3: MRI Imaging of Redox Active Fe Predicts GBM Responses to Pharmacological AscorbateP01CA217797 · NCI · UNIVERSITY OF IOWA · PI BUATTI, JOHN M · 2018 to 2022
$9.6M
University of Iowa Prevention Research Center for Rural HealthU48DP006389 · DP · UNIVERSITY OF IOWA · PI AFIFI, RIMA · 2018 to 2023
$7.4M
Rocky Mountain Prevention Research CenterU48DP006399 · DP · UNIVERSITY OF COLORADO DENVER · PI LEIFERMAN, JENN A, PUMA, JINI · 2018 to 2023
$6.9M
University of Iowa Surgical Oncology Training GrantT32CA148062 · NCI · UNIVERSITY OF IOWA · PI WEIGEL, RONALD J · 2010 to 2020
$3.8M
Pharmacological Ascorbate as a Radiosensitizer in Pancreatic CancerR01CA184051 · NCI · UNIVERSITY OF IOWA · PI CULLEN, JOSEPH J · 2015 to 2018
$1.4M
NCI NIH HHS P01 CA217797NCI NIH HHS P30 CA086862NCI NIH HHS R01 CA184051NCI NIH HHS T32 CA148062NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Pharmacological ascorbate (P-AscH

Indexed as

Antineoplastic AgentsAscorbic AcidMitochondriaMitochondrial DynamicsAnimalsCarcinoma, Pancreatic DuctalCell Line, TumorDynaminsExtracellular Signal-Regulated MAP KinasesFemaleHumansHydrogen PeroxideMiceOxidative StressPhosphorylationReactive Oxygen SpeciesAntineoplastic AgentsAscorbic AcidDNM1L protein, humanDynaminsExtracellular Signal-Regulated MAP KinasesHydrogen PeroxideReactive Oxygen SpeciesMitochondrial dynamicsMitochondrial fissionOxidative stressPharmacological ascorbate

Identifiers

PMID37137343
PMCPMC10375417
OpenAlexW4367835517

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.