ReviewChemical reviews2023
Late-Stage C-H Functionalization of Azines.
Review in Chemical reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Radical enantioconvergent meta-C─H alkylation of pyridines.Science advances · 2026Article
- Article
- Emerging Strategies forJACS Au · 2026Review
- Phosphonium Ions as Activating Groups for the Selective Alkylation of Pyridines and Polyazines.Journal of the American Chemical Society · 2026Article
- Divergent C2 functionalization of N-Heteroarenes via nonclassical rearomatization.Nature communications · 2026Article
- Photocatalytic Cross-Coupling of Phenols and Heteroaryl Halides With Machine Learning-Guided Reaction Prediction.Angewandte Chemie (International ed. in English) · 2026Article
- Reductive rearrangement of substituted quinolines to 2,3-disubstituted indoles enabled by water activation.Chemical science · 2026Article
- Pd-catalyzed sequential distal C-H alkenylation and π-allylic amination of arylacetic acids using MBH acetates: access to macrocyclic lactams.Chemical science · 2026Article
- Palladium-catalyzed selective assembly of carbamoylated indoles and aminophenanthridinones via β-carbon elimination switch.Communications chemistry · 2025Article
- Halogenated Pyridine Derivatives from Cycloaddition / Cycloreversion of Oxazinone and Haloalkyne Precursors.Tetrahedron letters · 2025Article
- Regiodivergent Deuteration of Pyridine-Based Heterocycles.Organic letters · 2025Article
- A Broadly Applicable Strategy to Aminate Azines Enabled by Electronically Tuned Phosphine Reagents.Angewandte Chemie (International ed. in English) · 2025Article
- Bioinspired transfer methylation enabled by a photoactive reagent.Nature communications · 2025Article
- Ni/NHC-catalyzed C5-H alkylation and alkenylation of challenging furan(thiophene)-2-carboxaldehydes enabled by recyclable imine protecting group.Communications chemistry · 2025Article
- Predictable C-H Functionalization of ComplexACS central science · 2025Article
- Late-Stage Heteroarene Alkylation via Minisci Reaction with Gaseous Alkanes Enabled by Hydrogen Atom Transfer in Flow.ACS central science · 2025Article
- Photocatalytic Hydrogenation of Quinolines to Form 1,2,3,4-Tetrahdyroquinolines Using Water as the Hydrogen Atom Donor.Angewandte Chemie (International ed. in English) · 2025Article
- An Oxygen Walk Approach for C3 Selective Hydroxylation of Pyridines.Synlett : accounts and rapid communications in synthetic organic chemistry · 2025Article
- Article
- Fluorescent pyridine phosphonium salts via transmutation of metallabenzenes.Nature communications · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widespread components of pharmaceuticals. Their occurrence derives from a suite of physiochemical properties that match key criteria in drug design and is tunable by varying their substituents. Developments in synthetic chemistry, therefore, directly impact these efforts, and methods that can install various groups from azine C-H bonds are particularly valuable. Furthermore, there is a growing interest in late-stage functionalization (LSF) reactions that focus on advanced candidate compounds that are often complex structures with multiple heterocycles, functional groups, and reactive sites. Because of factors such as their electron-deficient nature and the effects of the Lewis basic N atom, azine C-H functionalization reactions are often distinct from their arene counterparts, and the application of these reactions in LSF contexts is difficult. However, there have been many significant advances in azine LSF reactions, and this review will describe this progress, much of which has occurred over the past decade. It is possible to categorize these reactions as radical addition processes, metal-catalyzed C-H activation reactions, and transformations occurring via dearomatized intermediates. Substantial variation in reaction design within each category indicates both the rich reactivity of these heterocycles and the creativity of the approaches involved.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.