Evidence map›Paper›PMID 37134162›Full record

ArticleScience advances2023

Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress.

Ramya S Kuna, Avi Kumar, Karl A Wessendorf-Rodriguez, Hector Galvez, Courtney R Green, Grace H McGregor, Thekla Cordes, Reuben J Shaw, Robert U Svensson, Christian M Metallo

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Gut microbes · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Metabolic Reprogramming in Melanoma: An Epigenetic Point of View.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Ramya S KunaDepartment of Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0002-8104-4720
Avi KumarDepartment of Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0001-8673-9081
Karl A Wessendorf-RodriguezDepartment of Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Hector GalvezDepartment of Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0001-9331-6116
Courtney R GreenDepartment of Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0002-9279-0649
Grace H McGregorDepartment of Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0002-1822-8789
Thekla CordesDepartment of Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0002-8097-191X
Reuben J ShawDepartment of Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0002-1555-8977
Robert U SvenssonNimbus Therapeutics, Cambridge, MA 02139, USA.
Christian M MetalloDepartment of Molecular and Cell Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0003-2404-3040
Salk Institute for Biological Studies · USEnsemble Therapeutics (United States) · US

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8M
Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9M
Research Education CoreU54CA132379 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ARREDONDO, ELVA M, CROWE, SHEILA E. · 2008 to 2021
$16.1M
Decoding And Targeting The LKB1-AMPK Signaling Pathway In CancerR35CA220538 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 2017 to 2026
$11.3M
MOLECULAR BIOLOGICAL APPROACHES TO ENDOCRINOLOGYT32DK007541 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAULTON, KYLE JEFFRIE, MAJITHIA, AMIT · 1987 to 2022
$4.5M
Non-essential amino acids and sphingolipid diversity in cancer progressionR01CA234245 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI METALLO, CHRISTIAN MICHAEL · 2019 to 2023
$1.9M
NCI NIH HHS P01 CA120964NCI NIH HHS P30 CA014195NCI NIH HHS R01 CA234245NCI NIH HHS R35 CA220538NCI NIH HHS U54 CA132379NIDDK NIH HHS T32 DK007541
6 · The paper itself

Abstract

Proliferating cells rely on acetyl-CoA to support membrane biogenesis and acetylation. Several organelle-specific pathways are available for provision of acetyl-CoA as nutrient availability fluctuates, so understanding how cells maintain acetyl-CoA homeostasis under such stresses is critically important. To this end, we applied

Indexed as

AcetatesLipogenesisAcetyl Coenzyme AATP Citrate (pro-S)-LyaseHomeostasisMitochondriaStress, PhysiologicalAcetatesAcetyl Coenzyme AATP Citrate (pro-S)-Lyase

Identifiers

PMID37134162
PMCPMC10156121
OpenAlexW4367857044

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.