Evidence map›Paper›PMID 37134158›Full record

ArticleScience advances2023

Skin-interfaced microfluidic systems with spatially engineered 3D fluidics for sweat capture and analysis.

Chung-Han Wu, Howin Jian Hing Ma, Paul Baessler, Roxanne Kate Balanay, Tyler R Ray

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
8.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 73 citations in OpenAlex.

  1. Review
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  7. Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Lab on an end: Micromanipulation using the acoustohydrodynamic pillar array as an end effector.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chung-Han WuDepartment of Mechanical Engineering, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.ORCID 0000-0003-3335-7818
Howin Jian Hing MaDepartment of Mechanical Engineering, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.
Paul BaesslerDepartment of Mechanical Engineering, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.
Roxanne Kate BalanayDepartment of Mechanical Engineering, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.
Tyler R RayDepartment of Mechanical Engineering, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.ORCID 0000-0001-7047-9676
University of Hawaiʻi at Mānoa · US

Funding

TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Michael A. Ortega · 2017 to 2026
$21.5M
NIGMS NIH HHS P20 GM113134
6 · The paper itself

Abstract

Skin-interfaced wearable systems with integrated microfluidic structures and sensing capabilities offer powerful platforms for monitoring the signals arising from natural physiological processes. This paper introduces a set of strategies, processing approaches, and microfluidic designs that harness recent advances in additive manufacturing [three-dimensional (3D) printing] to establish a unique class of epidermal microfluidic ("epifluidic") devices. A 3D printed epifluidic platform, called a "sweatainer," demonstrates the potential of a true 3D design space for microfluidics through the fabrication of fluidic components with previously inaccessible complex architectures. These concepts support integration of colorimetric assays to facilitate in situ biomarker analysis operating in a mode analogous to traditional epifluidic systems. The sweatainer system enables a new mode of sweat collection, termed multidraw, which facilitates the collection of multiple, independent sweat samples for either on-body or external analysis. Field studies of the sweatainer system demonstrate the practical potential of these concepts.

Indexed as

MicrofluidicsSweatEpidermisLab-On-A-Chip DevicesSkin

Identifiers

PMID37134158
PMCPMC10881187
OpenAlexW4367856162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.