Evidence map›Paper›PMID 37134016›Full record

ArticleJBRA assisted reproduction2023

Flexible Antagonist versus Agonist Flare Protocol in Women above 40 Undergoing IVF, A retrospective Cohort Study.

Elsayed Ali Farag Hassabelnabi, Mohammad Ahmad Badreldin, Mohammad Atef Behery, Kamaleldin Abdullah Rageh, Eman Ahmed Ali

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Article in JBRA assisted reproduction, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Elsayed Ali Farag HassabelnabiAlmana General Hospital, IVF unit, Eastern Provence, Saudi Arabia.
Mohammad Ahmad BadreldinAlmana General Hospital, IVF unit, Eastern Provence, Saudi Arabia.
Mohammad Atef BeheryAssisted Reproduction Unit, The International Islamic Center for Population Studies and Research, Al-Azhar University, Cairo, Egypt.
Kamaleldin Abdullah RagehDepartment of Obstetrics and Gynecology, Faculty of medicine, Al-Azhar University, Cairo, Egypt.
Eman Ahmed AliAssisted Reproduction Unit, The International Islamic Center for Population Studies and Research, Al-Azhar University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSeveral strategies have been proposed for ovarian stimulation in older women, such as using an increased daily dose of gonadotropins (300-450 IU per day) with GnRH agonist (long or micro dose flare protocols), or using GnRH antagonist protocols. The objective of this study is to compare the efficacy of flexible GnRH antagonist protocol and GnRH agonist flare - pituitary block protocols for ovarian stimulation in women above 40 years old undergoing IVF.

methodsThis study was performed between January 2016 and February 2019. One hundred and fourteen women aged between 40 and 42 years who underwent IVF were divided into two groups; group I were treated by Flexible GnRH antagonist protocol (Antagonist group, n=68); and group II were treated by Flare GnRH agonist protocol (Flare group, n=46).

resultsPatients treated with the antagonist protocol had a significantly lower cancellation rate when compared with patients treated with flare agonist protocol (10.3% vs. 21.7%, p value 0.049). The other parameters evaluated did not show statistically significant differences.

conclusionsOur finding showed that both Flexible antagonist and Flare agonist protocols had comparable outcomes, with lower cycle cancellation rates for older patients treated with the antagonist protocol.

Indexed as

Fertilization in VitroGonadotropin-Releasing HormoneAdultAgedFemaleHormone AntagonistsHumansOvulation InductionPregnancyPregnancy RateRetrospective StudiesGonadotropin-Releasing HormoneHormone Antagonistscontrolled ovarian stimulationflare protocolGnRH antagonist protocolIVF outcome

Identifiers

PMID37134016
PMCPMC10712806

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