Evidence map›Paper›PMID 37133762›Full record

SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2023

Application of rhBMP in spinal fusion surgery: any correlation of cancer incidence? A systematic review and meta-analysis.

Jeremiah Hilkiah Wijaya, Teddy Tjahyanto, Roberto Alexi, Alexander Erick Purnomo, Louis Rianto, Yang Yang Endro Arjuna, Jephtah Furano Lumban Tobing, Yesaya Yunus, Ahmad Faried

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jeremiah Hilkiah WijayaDepartment of Neurosurgery, Universitas Pelita Harapan, MH Thamrin Boulevard 1100, Karawaci, Tangerang, 15811, Banten, Indonesia. jeremiah.hansum6@gmail.com.ORCID http://orcid.org/0000-0001-8771-2163
Teddy TjahyantoDepartment of Medicine, Tarumanagara University, Jakarta, Indonesia.
Roberto AlexiDepartment of Medicine, Santo Vincentius Hospital, Singkawang, West Kalimantan, Indonesia.
Alexander Erick PurnomoDepartment of Neurosurgery, Universitas Pelita Harapan, MH Thamrin Boulevard 1100, Karawaci, Tangerang, 15811, Banten, Indonesia.
Louis RiantoDepartment of Orthopedics, Universitas Pelita Harapan, Karawaci, Tangerang, Banten, Indonesia.
Yang Yang Endro ArjunaDepartment of Neurosurgery, Universitas Pelita Harapan, MH Thamrin Boulevard 1100, Karawaci, Tangerang, 15811, Banten, Indonesia.
Jephtah Furano Lumban TobingDepartment of Orthopedics, Universitas Pelita Harapan, Karawaci, Tangerang, Banten, Indonesia.
Yesaya YunusDepartment of Neurosurgery, Universitas Pelita Harapan, MH Thamrin Boulevard 1100, Karawaci, Tangerang, 15811, Banten, Indonesia.
Ahmad FariedDepartment of Neurosurgery, Universitas Padjajaran, Bandung, West Java, Indonesia.
Pelita Harapan University · IDPadjadjaran University · IDTarumanagara University · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSafety concerns regarding the application of bone morphogenetic proteins (BMPs) have been highlighted in recent years. It is noted that both BMP and their receptors being identified as a trigger for cancer growth. Here, we aimed to determine the safety and efficacy of BMP for spinal fusion surgery.

methodsWe conducted this systematic review on topics of spinal fusion surgery with rhBMP application from three database (PubMed, EuropePMC, and Clinicaltrials.gov) with MeSH phrases such as "rh-BMP," "rhBMP," "spine surgery," "spinal arthrodesis," and "spinal fusion" were searched (using the Boolean operators "and" and "or"). Our research includes all articles, as long as published in English language. In the face of disagreement between the two reviewers, we discussed it together until all authors reached a consensus. The primary key outcome of our study is the incidence of cancer following rhBMP implantation.

resultsOur study included a total of 8 unique studies (n = 37,682). The mean follow-up varies among all studies, with the longest follow-up is 66 months. Our meta-analysis showed that exposure to rhBMP in spinal surgery did increase the risk of cancers (RR 1.85, 95%CI [1.05, 3.24], p = 0.03).

conclusionsOur study found that rhBMP was not associated with the increased risk of cancer incidence within the rhBMP cohort. Still, we did face several limitations, in which further studies are needed to confirm the result of our meta-analysis.

Indexed as

NeoplasmsSpinal FusionBone Morphogenetic Protein 2HumansIncidenceNeurosurgical ProceduresRecombinant ProteinsTransforming Growth Factor betaBone Morphogenetic Protein 2Recombinant ProteinsTransforming Growth Factor betaCancerrhBMPSpinal fusion surgery

Identifiers

PMID37133762
OpenAlexW4367835020

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.