Observational studyAdvances in therapy2023
Patient Management and Clinical Outcomes Associated with a Recorded Diagnosis of Stage 3 Chronic Kidney Disease: The REVEAL-CKD Study.
Observational study in Advances in therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04847531 (REVEAL-CKD), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
REVEAL-CKD: A Retrospective, Multinational Observational Study to Determine the Prevalence and Consequences of Undiagnosed Chronic Kidney Disease
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Pooled it
- Underutilization of albuminuria screening in adults with diabetes mellitus or hypertension: a systematic review and meta-analysis.BMC nephrology · 2025Pooled it
- Quality of care for people with chronic kidney disease: a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Effects of Psychological Empowerment-Based Motivational Interviewing Program on Self-Management Behavior in Patients With Early Chronic Kidney Disease: A Mixed Methods Study.Journal of nursing management · 2025Trial
- Gender disparities in Swedish specialized nephrology care.Clinical kidney journal · 2026Article
- Improving diabetic kidney disease screening in a VA resident primary care clinic: a quality improvement initiative.BMJ open quality · 2026Article
- A Microsimulation-Based Approach for Mitigating Societal Bias in Chronic Kidney Disease Data.Medical decision making : an international journal of the Society for Medical Decision Making · 2026Article
- Randomized clinical trial of the KH4L self-management program.Clinical kidney journal · 2026Article
- Multiparametric MRI for Predicting Renal Function Deterioration and Chronic Kidney Disease Development in Patients Undergoing Nephrectomy for Renal Masses: A Pilot Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Chronic kidney disease screening to reduce cardiovascular risk: a call to action.American journal of preventive cardiology · 2026Article
- Implementing a model of integrated CKD management between primary and secondary care.Clinical kidney journal · 2026Review
- Combined use of ultrasonography and point shear wave elastography for the assessment of renal diseases.Frontiers in medicine · 2026Article
- Comparison of risks and costs of undiagnosed and diagnosed chronic kidney disease patients after the initiation of kidney replacement therapy in subsequent years. A Hungarian nationwide study.Frontiers in medicine · 2026Article
- Predicting 1-Year Renal Outcomes in Patients with Diabetic Kidney Disease in CKD Stages 3 to 4: A Multimodal Machine Learning Approach Fusing Clinical Composites and Pathology Images.Research (Washington, D.C.) · 2026Article
- Development and evaluation of an AI-based prediction model for chronic kidney disease after cardiac surgery.BMJ digital health & AI · 2026Article
- Assessing the landscape of initiatives to improve CKD early diagnosis and treatment.BMC nephrology · 2025Article
- A microsimulation-based framework for mitigating societal bias in primary care data.medRxiv : the preprint server for health sciences · 2025Article
- Differences in chronic kidney disease management based on identification and diagnosis in a population-based observational study.Journal of nephrology · 2025Observational
- Detecting early kidney allograft fibrosis with multi-b-value spectral diffusion MRI.Scientific reports · 2025Article
- Creatinine Decline Rate as a Predictor of Renal Recovery After Acute Kidney Injury: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGuidelines for the treatment of chronic kidney disease (CKD) recommend early intervention and management to slow disease progression. However, associations between diagnosis and CKD progression are not fully understood.
methodsREVEAL-CKD (NCT04847531) is a retrospective observational study of patients with stage 3 CKD. Data were extracted from the US TriNetX database. Eligible patients had two consecutive estimated glomerular filtration rate (eGFR) measurements indicative of stage 3 CKD (≥ 30 and < 60 ml/min/1.73 m
resultsThe study included 26,851 patients. After diagnosis, we observed significant increases in the prescribing rate of guideline-recommended medications such as angiotensin-converting enzyme inhibitors (rate ratio [95% confidence interval]: 1.87 [1.82, 1.93]), angiotensin receptor blockers (1.91 [1.85, 1.97]) and mineralocorticoid receptor antagonists (2.23 [2.13, 2.34]). Annual eGFR decline was significantly reduced following a CKD diagnosis, from 3.20 ml/min/1.73 m
conclusionsA recorded CKD diagnosis was associated with significant improvements in CKD management and monitoring practices and attenuated eGFR decline. Recorded diagnosis of stage 3 CKD is an important first step to reduce the risk of disease progression and minimize adverse clinical outcomes.
trial registrationClinicalTrials.gov identifier, NCT04847531.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.