Evidence map›Paper›PMID 37133500›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2023

Drusen morphometrics on optical coherence tomography in eyes with age-related macular degeneration and normal aging.

Deniz Oncel, Giulia Corradetti, Yu Wakatsuki, Muneeswar Gupta Nittala, Swetha Bindu Velaga, Dwight Stambolian, Margaret A Pericak-Vance, Jonathan L Haines, SriniVas R Sadda

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Deniz OncelDoheny Eye Institute, Los Angeles, CA, USA.
Giulia CorradettiDoheny Eye Institute, Los Angeles, CA, USA.
Yu WakatsukiDoheny Eye Institute, Los Angeles, CA, USA.
Muneeswar Gupta NittalaDoheny Eye Institute, Los Angeles, CA, USA.
Swetha Bindu VelagaDoheny Eye Institute, Los Angeles, CA, USA.
Dwight StambolianOphthalmology and Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Margaret A Pericak-VanceHussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Jonathan L HainesDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
SriniVas R SaddaDoheny Eye Institute, Los Angeles, CA, USA. ssadda@doheny.org.ORCID http://orcid.org/0000-0002-4939-3306
University of California, Los Angeles · USCase Western Reserve University · USDoheny Eye Institute · USUniversity of Miami · USUniversity of Pennsylvania · US

Funding

Genetic Epidemiology of Age-Related Macular Degeneration in the Older Order AmishR01EY023164 · NEI · UNIVERSITY OF PENNSYLVANIA · PI PERICAK-VANCE, MARGARET A., STAMBOLIAN, DWIGHT EDWARD · 2013 to 2017
$6.2M
Epidemiology of Biomarkers of AMD ProgressionR01EY030614 · NEI · DOHENY EYE INSTITUTE · PI Jonathan L Haines, Margaret A. Pericak-Vance · 2021 to 2026
$3.0M
NEI NIH HHS R01 EY023164NEI NIH HHS R01 EY030614NEI NIH HHS R01EY030614NEI NIH HHS RO1EY023164
6 · The paper itself

Abstract

purposeTo compare drusen size metrics (apical height and basal width) on optical coherence tomography (OCT) B-scans with their size assessed on color photos in eyes with age-related macular degeneration (AMD) and normal aging.

methodsA total of 508 drusen were evaluated in this analysis. Flash color fundus photos (CFP), infrared reflectance (IR) images, and OCT B-scans obtained at the same visit were evaluated. Individual drusen were identified on CFPs and the diameters of the drusen were measured in planimetric grading software. CFPs were manually registered to the IR image with their corresponding OCT volume. After confirming correspondence between the CFP and OCT, the apical height and basal width of the same drusen were measured on OCT B-scans.

resultsDrusen were divided into small, medium, large, and very large categories based on their diameter on the CFP images (< 63, 63 to 124, 125 to 249, and [Formula: see text] 250 μm, respectively). The OCT apical height of small drusen on CFP ranged from 20 to 31 μm, while medium drusen ranged from 31 to 46 μm, large drusen ranged from 45 μm to 111 µm, and very large drusen ranged from 55 μm to 208 μm. The OCT basal width measured < 99 μm in small drusen, from 99 to 143 μm in medium drusen, from 141 to 407 µm in large drusen, and > 209 µm in very large drusen.

conclusionDrusen of different size categories on color photographs may also be separated according to their apical height and basal width on OCT. The apical height and basal width ranges defined in this analysis may be of value in the design of an OCT-based grading scale for AMD.

Indexed as

Macular DegenerationRetinal DrusenAgingFluorescein AngiographyHumansRetinaTomography, Optical CoherenceAge-related macular degenerationAMDCFPColor fundus photographyDrusenOCT

Identifiers

PMID37133500
PMCPMC10527978
OpenAlexW4367835296

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.