Evidence map›Paper›PMID 37132544›Full record

ArticlePigment cell & melanoma research2023

BMI1 is required for melanocyte stem cell maintenance and hair pigmentation.

Molly M Wilson, Paul S Danielian, Griffin Salus, Roberta Ferretti, Charles A Whittaker, Jacqueline A Lees

Open access · hybridAbstract read
In one paragraph

Article in Pigment cell & melanoma research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Molly M WilsonDavid H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, USA.
Paul S DanielianDavid H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, USA.
Griffin SalusDavid H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, USA.
Roberta FerrettiDavid H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, USA.
Charles A WhittakerDavid H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, USA.
Jacqueline A LeesDavid H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, USA.ORCID 0000-0001-9451-2194
Allen Institute · US

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Paula T Hammond · 1985 to 2026
$93.9M
USE OF RETROVIRUS PROMOTER TRAP VECTORS TO IDENTIFY ONCOGENES AND ANTI-ONCOGENESP01CA042063 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JACKS, TYLER E. · 1986 to 2021
$30.5M
NCI NIH HHS P01 CA042063NCI NIH HHS P30 CA014051
6 · The paper itself

Abstract

The epigenetic repressor BMI1 plays an integral role in promoting the self-renewal and proliferation of many adult stem cell populations, and also tumor types, primarily through silencing the Cdkn2a locus, which encodes the tumor suppressors p16

Indexed as

MelanomaSkin NeoplasmsAnimalsCyclin-Dependent Kinase Inhibitor p16HairMelanocytesMicePigmentationPolycomb Repressive Complex 1Proto-Oncogene ProteinsStem CellsCyclin-Dependent Kinase Inhibitor p16Polycomb Repressive Complex 1Proto-Oncogene Proteinsepigenetic repressionhair folliclemelanocytesPolycomb repressive complex 1stem cells

Identifiers

PMID37132544
PMCPMC11344272
OpenAlexW4367835289

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.