ArticleThe Plant cell2023
The miR165/166-PHABULOSA module promotes thermotolerance by transcriptionally and posttranslationally regulating HSFA1.
Article in The Plant cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
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- Physiological Responses, Molecular Basis, and Integrated Regulation of Heat Tolerance in Soybean.Plants (Basel, Switzerland) · 2026Review
- Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The miR319/bHLH094 Module Regulates Creeping Bentgrass Thermotolerance by Modulating Auxin Biosynthesis and Signalling Pathway.Plant biotechnology journal · 2026Article
- miR172-Mediated Repression ofInternational journal of molecular sciences · 2026Article
- Genome-wide identification of Hsf gene family in citrus and functional analysis of CsHsfA1a in heat stress response.Plant cell reports · 2026Article
- MsmiR171 targetsHorticulture research · 2026Article
- Integrative characterization of the heat shock transcription factors inFrontiers in plant science · 2026Article
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- Exogenous Melatonin Induces Salt Stress Tolerance in Cucumber by Promoting Plant Growth and Defense System.Life (Basel, Switzerland) · 2025Article
- When the heat is on, HYL1 steps in: Regulating miRNA biogenesis for plant thermotolerance.The Plant cell · 2025Article
- Heat stress triggers enhanced nuclear localization of HYPONASTIC LEAVES 1 to regulate microRNA biogenesis and thermotolerance in plants.The Plant cell · 2025Article
- Methyl jasmonate induces the regulation of protostane triterpene biosynthesis by microRNAs in Alisma orientale.Protoplasma · 2025Article
- miRNA-seq analysis revealed a potential strategy underlying poplar root responses to low nitrogen stress.Planta · 2025Article
- Integrative Transcriptomic and Small RNA Analysis Uncovers Key Genes for Cold Resistance in Rice.Genes · 2024Article
- The Jasmonic Acid Biosynthetic Genes SmLOX4 and SmLOX5 Are Involved in Heat Tolerance in Eggplant.Plant & cell physiology · 2024Article
- Suppression of SMXL4 and SMXL5 confers enhanced thermotolerance through promoting HSFA2 transcription in Arabidopsis.The Plant cell · 2024Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress (HS) adversely affects plant growth and productivity. The Class A1 HS transcription factors (HSFA1s) act as master regulators in the plant response to HS. However, how HSFA1-mediated transcriptional reprogramming is modulated during HS remains to be elucidated. Here, we report that a module formed by the microRNAs miR165 and miR166 and their target transcript, PHABULOSA (PHB), regulates HSFA1 at the transcriptional and translational levels to control plant HS responses. HS-triggered induction of MIR165/166 in Arabidopsis thaliana led to decreased expression of target genes including PHB. MIR165/166 overexpression lines and mutations in miR165/166 target genes enhanced HS tolerance, whereas miR165/166 knockdown lines and plants expressing a miR165/166-resistant form of PHB were sensitive to HS. PHB directly repressed the transcription of HSFA1s and globally modulated the expression of HS-responsive genes. PHB and HSFA1s share a common target gene, HSFA2, which is essential for activation of plant responses to HS. PHB physically interacted with HSFA1s and exerted an antagonistic effect on HSFA1 transcriptional activity. PHB and HSFA1s co-regulated transcriptome reprogramming upon HS. Together, these findings indicate that heat-triggered regulation of the miR165/166-PHB module controls HSFA1-mediated transcriptional reprogramming and plays a critical role during HS in Arabidopsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.