Evidence map›Paper›PMID 37132164›Full record

ArticlePublic health nursing (Boston, Mass.)

Exploratory assessment: Nurse-led community health worker delivered HCV intervention for people experiencing homelessness.

Adeline Nyamathi, Benissa E Salem, Darlene Lee, Zhaoxia Yu, Angela Hudson, Sammy Saab, Sanghyuk S Shin, Alexandria Jones-Patten, Kartik Yadav, Mitra Alikhani and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Public health nursing (Boston, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Adeline NyamathiUniversity of California, Irvine, Sue & Bill Gross School of Nursing, Irvine, California.
Benissa E SalemUniversity of California, Los Angeles, School of Nursing, Los Angeles, California.
Darlene LeeUniversity of California, Irvine, Susan Samueli Integrative Health Institute, Irvine, California.
Zhaoxia YuUniversity of California, Irvine, Department of Statistics, School of Information and Computer Sciences, Irvine, California.
Angela HudsonSamuel Merritt University, Oakland, California.
Sammy SaabAdult Liver Transplant Program, University of California, Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California.
Sanghyuk S ShinUniversity of California, Irvine, Sue & Bill Gross School of Nursing, Irvine, California.
Alexandria Jones-PattenUniversity of California, Irvine, Sue & Bill Gross School of Nursing, Irvine, California.ORCID 0000-0002-6302-0899
Kartik YadavUniversity of California, Irvine, Sue & Bill Gross School of Nursing, Irvine, California.
Mitra AlikhaniUniversity of California, Los Angeles, School of Nursing, Los Angeles, California.
Richard ClarkeUniversity of California, Irvine, Sue & Bill Gross School of Nursing, Irvine, California.
Alicia ChangLos Angeles County Department of Public Health, Community Field Services, Inglewood, California.
Kathryn WhiteLos Angeles Christian Health Centers, Los Angeles, California.
Lillian GelbergDavid Geffen School of Medicine at UCLA, UCLA Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California.
University of California, Irvine · USUniversity of California, Los Angeles · USLos Angeles County Department of Public Health · USSamuel Merritt University · US

Funding

Development of a Community-based HCV Treatment Completion Intervention Among HCV Positive Homeless AdultsR21MD013580 · NIMHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI GELBERG, LILLIAN, NYAMATHI, ADELINE M · 2019 to 2020
$445k
NIMHD NIH HHS R21 MD013580
6 · The paper itself

Abstract

backgroundGetting and maintaining Hepatitis C Virus (HCV) cure is challenging among people experiencing homelessness (PEH) as a result of critical social determinants of health such as unstable housing, mental health disorders, and drug and alcohol use.

objectivesThe purpose of this exploratory pilot study was to compare a registered nurse/community health worker (RN/CHW)-led HCV intervention tailored for PEH, "I am HCV Free," with a clinic-based standard of care (cbSOC) for treating HCV. Efficacy was measured by sustained virological response at 12 weeks after stopping antivirals (SVR12), and improvement in mental health, drug and alcohol use, and access to healthcare.

methodsAn exploratory randomized controlled trial design was used to assign PEH recruited from partner sites in the Skid Row Area of Los Angeles, California, to the RN/CHW or cbSOC programs. All received direct-acting antivirals. The RN/CHW group received directly observed therapy in community-based settings, incentives for taking HCV medications, and wrap-around services, including connection to additional healthcare services, housing support, and referral to other community services. For all PEH, drug and alcohol use and mental health symptoms were measured at month 2 or 3 and 5 or 6 follow-up, depending on HCV medication type, while SVR12 was measured at month 5 or 6 follow-up.

resultsAmong PEH in the RN/CHW group, 75% (3 of 4) completed SVR12 and all three attained undetectable viral load. This was compared with 66.7% (n = 4 of 6) of the cbSOC group who completed SVR12; all four attained undetectable viral load. The RN/CHW group, as compared to the cbSOC, also showed greater improvements in mental health, and significant improvement in drug use, and access to healthcare services. DISCUSSION: While this study shows significant improvements in drug use and health service access among the RN/-CHW group, the sample size of the study limits the validity and generalizability of the results. Further studies using larger sample sizes are necessitated.

Indexed as

Hepatitis CHepatitis C, ChronicIll-Housed PersonsAntiviral AgentsCommunity Health WorkersHepacivirusHumansNurse's RolePilot ProjectsAntiviral Agentshepatitis C virus treatmentpersons experiencing homelessnessRN/CHW intervention

Identifiers

PMID37132164
PMCPMC10524682
OpenAlexW4367835162

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.