Evidence map›Paper›PMID 37132119›Full record

ArticleTropical medicine & international health : TM & IH2023

Strategies to improve antiretroviral therapy (ART) initiation and early engagement among men in sub-Saharan Africa: A scoping review of interventions in the era of universal treatment.

Kathryn L Dovel, Santhi Hariprasad, Julie Hubbard, Morna Cornell, Khumbo Phiri, Augustine Choko, Rachel Abbott, Risa Hoffman, Brooke Nichols, Sundeep Gupta and 1 more

Abstract readScoping Review
In one paragraph

Article in Tropical medicine & international health : TM & IH, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kathryn L DovelDivision of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA.
Santhi HariprasadDepartment of Global Health, School of Public Health, Boston University, Boston, Massachusetts, USA.
Julie HubbardDivision of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA.
Morna CornellCentre for Infectious Disease Epidemiology & Research, School of Public Health, University of Cape Town, Cape Town, South Africa.
Khumbo PhiriPartners in Hope Medical Center, Lilongwe, Malawi.
Augustine ChokoUniversity of Malawi, College of Medicine, Blantyre, Malawi.
Rachel AbbottDivision of HIV, Infections Diseases & Global Medicine, University of California San Francisco, San Francisco, California, USA.
Risa HoffmanDivision of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA.
Brooke NicholsDepartment of Global Health, School of Public Health, Boston University, Boston, Massachusetts, USA.
Sundeep GuptaDivision of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA.
Lawrence LongDepartment of Global Health, School of Public Health, Boston University, Boston, Massachusetts, USA.

Funding

Observational Antiretroviral Studies In Southern Africa (OASIS) CollaborationU01AI069924 · NIAID · UNIVERSITAT BERN · PI Cleophas Chimbetete, Mary-Ann Davies · 2006 to 2026
$55.9M
Engaging men through HIV self-test and differentiated care models to increase ART initiation and viral suppression in MalawiR01MH122308 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DOVEL, KATHRYN L · 2020 to 2024
$2.7M
Building Research in Inter-Disciplinary Gender and HIV through the Social Sciences (The BRIDGES Programme)D43TW011308 · FIC · UNIVERSITY OF CAPE TOWN · PI COLVIN, CHRISTOPHER JAMES · 2019 to 2023
$1.7M
Using behavioral economics to improve the uptake of and persistence on pre-exposure prophylaxis in men who have sex with men to prevent HIV infectionK01MH119923 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LONG, LAWRENCE CAMDON · 2020 to 2024
$865k
Innovative strategies to increase ART Initiation and viral suppression among HIV+ men in MalawiK01TW011484 · FIC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DOVEL, KATHRYN L · 2019 to 2023
$717k
FIC NIH HHS D43 TW011308FIC NIH HHS K01 TW011484NIAID NIH HHS U01 AI069924NIMH NIH HHS K01 MH119923NIMH NIH HHS R01 MH122308
6 · The paper itself

Abstract

objectivesMen in sub-Saharan Africa (SSA) have lower rates of antiretroviral therapy (ART) initiation and higher rates of early default than women. Little is known about effective interventions to improve men's outcomes. We conducted a scoping review of interventions aimed to increase ART initiation and/or early retention among men in SSA since universal treatment policies were implemented.

methodsThree databases, HIV conference databases and grey literature were searched for studies published between January 2016 to May 2021 that reported on initiation and/or early retention among men. Eligibility criteria included: participants in SSA, data collected after universal treatment policies were implemented (2016-2021), quantitative data on ART initiation and/or early retention for males, general male population (not exclusively focused on key populations), intervention study (report outcomes for at least one non-standard service delivery strategy), and written in English.

resultsOf the 4351 sources retrieved, 15 (reporting on 16 interventions) met inclusion criteria. Of the 16 interventions, only two (2/16, 13%) exclusively focused on men. Five (5/16, 31%) were randomised control trials (RCT), one (1/16, 6%) was a retrospective cohort study, and 10 (10/16, 63%) did not have comparison groups. Thirteen (13/16, 81%) interventions measured ART initiation and six (6/16, 37%) measured early retention. Outcome definitions and time frames varied greatly, with seven (7/16, 44%) not specifying time frames at all. Five types of interventions were represented: optimising ART services at health facilities, community-based ART services, outreach support (such as reminders and facility escort), counselling and/or peer support, and conditional incentives. Across all intervention types, ART initiation rates ranged from 27% to 97% and early retention from 47% to 95%.

conclusionsDespite years of data of men's suboptimal ART outcomes, there is little high-quality evidence on interventions to increase men's ART initiation or early retention in SSA. Additional randomised or quasi-experimental studies are urgently needed.

Indexed as

HIV InfectionsAfrica South of the SaharaCounselingFemaleHealth FacilitiesHumansMaleRandomized Controlled Trials as Topiccare continuumevidence-based interventionsgender disparitiesmenscoping review

Identifiers

PMID37132119
PMCPMC10354296

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.