Evidence map›Paper›PMID 37131988›Full record

ArticlePeerJ2023

Antagonistic antimalarial properties of a methoxyamino chalcone derivative and 3-hydroxypyridinones in combination with dihydroartemisinin against

Tanyaluck Kampoun, Pimpisid Koonyosying, Jetsada Ruangsuriya, Parichat Prommana, Philip J Shaw, Sumalee Kamchonwongpaisan, Hery Suwito, Ni Nyoman Tri Puspaningsih, Chairat Uthaipibull, Somdet Srichairatanakool

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Tanyaluck KampounDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Pimpisid KoonyosyingDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Jetsada RuangsuriyaDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Parichat PrommanaMedical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand.
Philip J ShawMedical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand.ORCID 0000-0003-3913-3057
Sumalee KamchonwongpaisanMedical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand.
Hery SuwitoDepartment of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya, Indonesia.
Ni Nyoman Tri PuspaningsihLaboratory of Proteomics, University-CoE Research Center for Bio-Molecule Engineering, Universitas Airlangga, Surabaya, Indonesia.
Chairat UthaipibullMedical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, Thailand.ORCID 0000-0003-4941-2922
Somdet SrichairatanakoolDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Chiang Mai University · THNational Science and Technology Development Agency · THAirlangga University · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The spread of artemisinin (ART)-resistant Methods: In this study, methoxyamino chalcone (C3), an antimalarial compound that has been reported to inhibit the interaction of recombinant Fd and FNR proteins, was used as a chemical inhibitor of the Fd/FNR redox system. We investigated the inhibitory effects of dihydroartemisinin (DHA), C3, and iron chelators including deferiprone (DFP), 1-( Results: C3 showed antimalarial potency similar to that of the iron chelators. As expected, combining DHA with C3 or iron chelators exhibited a moderately antagonistic effect. No differences were observed among the mutant parasites with respect to their sensitivity to C3, iron chelators, or the interactions of these compounds with DHA. Discussion: The data suggest that inhibitors of the Fd/FNR redox system should be avoided as ART partner drugs in ART combination therapy for treating malaria.

Indexed as

AntimalarialsChalconeMalaria, FalciparumArtemisininsDeferiproneFerredoxin-NADP ReductaseFerredoxinsHumansIron Chelating AgentsPlasmodium falciparumAntimalarialsartemisininArtemisininsartenimolChalconeDeferiproneFerredoxin-NADP ReductaseFerredoxinsIron Chelating AgentsAntimalarialArtemisininChalconeDrug resistanceFerredoxinHydroxypyridinonePlasmodium

Identifiers

PMID37131988
PMCPMC10149052
OpenAlexW4367182161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.