Evidence map›Paper›PMID 37131840›Full record

ArticlebioRxiv : the preprint server for biology2023

PTEN knockout using retrogradely transported AAVs restores locomotor abilities in both acute and chronic spinal cord injury.

Andrew N Stewart, Reena Kumari, William M Bailey, Ethan P Glaser, Gabrielle V Hammers, Olivia H Wireman, John C Gensel

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andrew N StewartDepartment of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA.ORCID 0000-0003-0607-6578
Reena KumariDepartment of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA.
William M BaileyDepartment of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA.
Ethan P GlaserDepartment of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA.
Gabrielle V HammersDepartment of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA.
Olivia H WiremanDepartment of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA.
John C GenselDepartment of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA.ORCID 0000-0001-8980-108X
University of Kentucky · US

Funding

Macrophage Depletion Therapy for Spinal Cord InjuryR01NS116068 · NINDS · UNIVERSITY OF KENTUCKY · PI ALILAIN, WARREN JOSEPH, GENSEL, JOHN C · 2021 to 2025
$3.0M
Interdisciplinary Training in Alcohol ResearchT32AA027488 · NIAAA · UNIVERSITY OF KENTUCKY · PI Mark T Fillmore, Mark A Prendergast · 2019 to 2026
$2.0M
Role of Age on Anti-oxidant Defense in Spinal Cord Injury: Physiological Changes and InterventionF32NS111241 · NINDS · UNIVERSITY OF KENTUCKY · PI STEWART, ANDREW NATHANIEL · 2019 to 2021
$161k
The Role of Perilipin 2 in Macrophages after Experimental Spinal Cord InjuryF30NS129251 · NINDS · UNIVERSITY OF KENTUCKY · PI GLASER, ETHAN PHARES · 2022 to 2023
$104k
NIAAA NIH HHS T32 AA027488NINDS NIH HHS F30 NS129251NINDS NIH HHS F32 NS111241NINDS NIH HHS R01 NS116068
6 · The paper itself

Abstract

Restoring function in chronic stages of spinal cord injury (SCI) has often been met with failure or reduced efficacy when regenerative strategies are delayed past the acute or sub-acute stages of injury. Restoring function in the chronically injured spinal cord remains a critical challenge. We found that a single injection of retrogradely transported adeno-associated viruses (AAVrg) to knockout the phosphatase and tensin homolog protein (PTEN) in chronic SCI can effectively target both damaged and spared axons and restore locomotor functions in near-complete injury models. AAVrg's were injected to deliver cre recombinase and/or a red fluorescent protein (RFP) under the human Synapsin 1 promoter (hSyn1) into the spinal cords of C57BL/6 PTEN

Identifiers

PMID37131840
PMCPMC10153160
OpenAlexW4366202941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.