Evidence map›Paper›PMID 37131810›Full record

ArticlebioRxiv : the preprint server for biology2023

Scalable, flexible carbon fiber electrode thread arrays for three-dimensional spatial profiling of neurochemical activity in deep brain structures of rodents.

Mingyi Xia, Busra Nur Agca, Tomoko Yoshida, Jiwon Choi, Usamma Amjad, Kade Bose, Nikol Keren, Shahar Zukerman, Michael J Cima, Ann M Graybiel and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Mingyi XiaMcGovern Institute and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology.
Busra Nur AgcaMcGovern Institute and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology.
Tomoko YoshidaMcGovern Institute and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology.
Jiwon ChoiDepartment of Bioengineering, University of Pittsburgh.
Usamma AmjadDepartment of Bioengineering, University of Pittsburgh.
Kade BoseMcGovern Institute and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology.
Nikol KerenDepartment of Bioengineering, University of Pittsburgh.
Shahar ZukermanDepartment of Bioengineering, University of Pittsburgh.
Michael J CimaKoch Institute for Integrative Cancer Research and Department of Materials Science, Massachusetts Institute of Technology.
Ann M GraybielMcGovern Institute and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology.
Helen N SchwerdtDepartment of Bioengineering, University of Pittsburgh.
McGovern Institute for Brain Research · USUniversity of Pittsburgh · USMassachusetts Institute of Technology · US

Funding

Functional and anatomical characterization of the striosomal systemR01MH060379 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Ann M Graybiel · 2000 to 2026
$8.7M
Mapping neurochemical activity of the basal ganglia in pathological behaviorsR00NS107639 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHWERDT, HELEN N · 2021 to 2023
$747k
NIMH NIH HHS R01 MH060379NINDS NIH HHS R00 NS107639
6 · The paper itself

Abstract

We developed a flexible "electrode-thread" array for recording dopamine neurochemical activity from a lateral distribution of subcortical targets (up to 16) transverse to the axis of insertion. Ultrathin (∼ 10 µm diameter) carbon fiber (CF) electrode-threads (CFETs) are clustered into a tight bundle to introduce them into the brain from a single entry point. The individual CFETs splay laterally in deep brain tissue during insertion due to their innate flexibility. This spatial redistribution allows navigation of the CFETs towards deep brain targets spreading horizontally from the axis of insertion. Commercial "linear" arrays provide single entry insertion but only allow measurements along the axis of insertion. Horizontally configured neurochemical recording arrays inflict separate penetrations for each individual channel (i.e., electrode). We tested functional performance of our CFET arrays

Identifiers

PMID37131810
PMCPMC10153108
OpenAlexW4366203878

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.