Evidence map›Paper›PMID 37131734›Full record

ArticlebioRxiv : the preprint server for biology2023

Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency.

Jessica Root, Anarmaa Mendsaikhan, Srijita Nandy, Georgia Taylor, Minzheng Wang, Ludmilla Troiano Araujo, Paola Merino, Danny Ryu, Christopher Holler, Bonne M Thompson and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Jessica RootDepartment of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA 30322, USA.
Anarmaa MendsaikhanDepartment of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA 30322, USA.
Srijita NandyDepartment of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA 30322, USA.
Georgia TaylorDepartment of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA 30322, USA.
Minzheng WangDepartment of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA 30322, USA.
Ludmilla Troiano AraujoDepartment of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA 30322, USA.
Paola MerinoDepartment of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA 30322, USA.
Danny RyuDepartment of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA 30322, USA.
Christopher HollerArkuda Therapeutics, 200 Arsenal Yards Blvd Suite 220, Watertown, MA 02472, USA.
Bonne M ThompsonArkuda Therapeutics, 200 Arsenal Yards Blvd Suite 220, Watertown, MA 02472, USA.
Giuseppe AstaritaArkuda Therapeutics, 200 Arsenal Yards Blvd Suite 220, Watertown, MA 02472, USA.
Jean-François BlainArkuda Therapeutics, 200 Arsenal Yards Blvd Suite 220, Watertown, MA 02472, USA.
Thomas KukarDepartment of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA 30322, USA.
Emory University · US

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
Training In Systems And Integrative Biology NeuroscienceT32NS096050 · NINDS · EMORY UNIVERSITY · PI Yoland Smith · 2016 to 2026
$3.9M
Resolving the function of progranulin in lysosomal lipid metabolism and the etiology of Alzheimer's disease and frontotemporal dementiaRF1AG079318 · NIA · EMORY UNIVERSITY · PI KUKAR, THOMAS L · 2022 to 2025
$3.5M
Molecular mechanisms of Progranulin in NeurodegenerationR01NS105971 · NINDS · EMORY UNIVERSITY · PI KUKAR, THOMAS L · 2018 to 2022
$1.9M
Defining the role of FUS phosphorylation in neurodegenerationR01NS093362 · NINDS · EMORY UNIVERSITY · PI KUKAR, THOMAS L · 2015 to 2019
$1.7M
Elucidating molecular mechanisms of lysosomal dysfunction underlying progranulin deficiencyF31NS117129 · NINDS · EMORY UNIVERSITY · PI ROOT, JESSICA TURNER · 2021 to 2023
$122k
NCI NIH HHS P30 CA138292NIA NIH HHS RF1 AG079318NINDS NIH HHS F31 NS117129NINDS NIH HHS R01 NS093362NINDS NIH HHS R01 NS105971NINDS NIH HHS T32 NS096050
6 · The paper itself

Abstract

Progranulin (PGRN) deficiency is linked to neurodegenerative diseases including frontotemporal dementia, Alzheimer's disease, Parkinson's disease, and neuronal ceroid lipofuscinosis. Proper PGRN levels are critical to maintain brain health and neuronal survival, however the function of PGRN is not well understood. PGRN is composed of 7.5 tandem repeat domains, called granulins, and is proteolytically processed into individual granulins inside the lysosome. The neuroprotective effects of full-length PGRN are well-documented, but the role of granulins is still unclear. Here we report, for the first time, that expression of single granulins is sufficient to rescue the full spectrum of disease pathology in mice with complete PGRN deficiency (

Indexed as

Alzheimer’s disease (AD)frontotemporal dementia (FTD)galectin-3granulinslipid dysfunctionlipidomicslipofuscinlysosomemetabolomicsneuroinflammationprogranulinproteomics

Identifiers

PMID37131734
PMCPMC10153205
OpenAlexW4366333901

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.