Evidence map›Paper›PMID 37131706›Full record

ArticlebioRxiv : the preprint server for biology2023

Loss of ASD-Related Molecule Cntnap2 Affects Colonic Motility in Mice.

Beatriz G Robinson, Beau A Oster, Keiramarie Robertson, Julia A Kaltschmidt

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Beatriz G RobinsonWu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
Beau A OsterNevada ENDURE Program, University of Nevada, Reno, Reno, NV 89557, USA.
Keiramarie RobertsonWu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
Julia A KaltschmidtWu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
Neurosciences Institute · USUniversity of Nevada, Reno · US

Funding

Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2M
BP-ENDURE at the University of NevadaR25NS119709 · NINDS · UNIVERSITY OF NEVADA RENO · PI Marian E Berryhill, Dennis Mathew · 2021 to 2026
$2.6M
NIMH NIH HHS T32 MH020016NINDS NIH HHS R25 NS119709
6 · The paper itself

Abstract

Gastrointestinal (GI) symptoms are highly prevalent among individuals with autism spectrum disorder (ASD), but the molecular link between ASD and GI dysfunction remains poorly understood. The enteric nervous system (ENS) is critical for normal GI motility and has been shown to be altered in mouse models of ASD and other neurological disorders. Contactin-associated protein-like 2 (Cntnap2) is an ASD-related synaptic cell-adhesion molecule important for sensory processing. In this study, we examine the role of Cntnap2 in GI motility by characterizing Cntnap2's expression in the ENS and assessing GI function in

Indexed as

Autism spectrum disorder (ASD)Caspr2Cntnap2enteric nervous systemgastrointestinal dysmotilitysensory neurons

Identifiers

PMID37131706
PMCPMC10153124
OpenAlexW4366578446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.