Evidence map›Paper›PMID 37131681›Full record

ArticlebioRxiv : the preprint server for biology2023

Conserved enhancer logic controls the notochord expression of vertebrate

Cassie L Kemmler, Jana Smolikova, Hannah R Moran, Brandon J Mannion, Dunja Knapp, Fabian Lim, Anna Czarkwiani, Viviana Hermosilla Aguayo, Vincent Rapp, Olivia E Fitch and 10 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 5 countries.

Cassie L KemmlerSection of Developmental Biology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jana SmolikovaInstitute of Molecular Genetics of the ASCR, v. v. i., Prague, Czech Republic.
Hannah R MoranSection of Developmental Biology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Brandon J MannionEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Dunja KnappTechnische Universität Dresden, CRTD/Center for Regenerative Therapies Dresden, Dresden, Germany.
Fabian LimDepartment of Medicine, Health Sciences, University of California San Diego, La Jolla, CA, USA.
Anna CzarkwianiTechnische Universität Dresden, CRTD/Center for Regenerative Therapies Dresden, Dresden, Germany.
Viviana Hermosilla AguayoProgram in Craniofacial Biology, University of California San Francisco, San Francisco, CA, USA.
Vincent RappDepartment for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.
Olivia E FitchDepartment of Integrative Biology and Ecology, Evolution and Behavior Program, Michigan State University, East Lansing, MI, USA.
Seraina BötschiInstitute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Licia SelleriProgram in Craniofacial Biology, University of California San Francisco, San Francisco, CA, USA.
Emma FarleyDepartment of Medicine, Health Sciences, University of California San Diego, La Jolla, CA, USA.
Ingo BraaschDepartment of Integrative Biology and Ecology, Evolution and Behavior Program, Michigan State University, East Lansing, MI, USA.
Maximina YunTechnische Universität Dresden, CRTD/Center for Regenerative Therapies Dresden, Dresden, Germany.
Axel ViselEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Marco OsterwalderEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Christian MosimannSection of Developmental Biology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Zbynek KozmikInstitute of Molecular Genetics of the ASCR, v. v. i., Prague, Czech Republic.
Alexa BurgerSection of Developmental Biology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
University of Colorado Anschutz Medical Campus · USCollegeAmerica · USInstitute of Molecular Genetics · RULawrence Berkeley National Laboratory · USMichigan State University · USTechnische Universität Dresden · DEUniversity of Bern · CHUniversity of California, San Francisco · USMax Planck Institute of Molecular Cell Biology and Genetics · DEUniversity of Zurich · CH

Funding

Generation of an In Vivo Human Genome Transcriptional Enhancer DatasetR01HG003988 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio · 2006 to 2026
$24.1M
Pbx-Directed Control of Cellular Behaviors that Drive Midface MorphogenesisR01DE024745 · NIDCR · WEILL MEDICAL COLL OF CORNELL UNIV · PI SELLERI, LICIA · 2015 to 2025
$5.1M
A Single-Cell Resolution Enhancer Atlas of Craniofacial DevelopmentR01DE028599 · NIDCR · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI VISEL, AXEL · 2019 to 2023
$4.2M
In vivo Characterization of Regulatory Variant Pathogenicity in Congenital Heart DiseaseR01HL162304 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PENNACCHIO, LEN ALEXANDER, VISEL, AXEL · 2022 to 2025
$3.0M
Deciphering the regulatory principles governing enhancer specificityDP2HG010013 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARLEY, EMMA KIRSTEN · 2017 to 2021
$2.5M
Predoctoral Training in the Genetics of Development, Disease and RegenerationT32GM141742 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Bruce H Appel, Jeffrey Kyle Moore · 2021 to 2026
$1.9M
Developmental causes of syndromic Thrombocytopenia and co-morbiditiesR01DK129350 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BURGER, ALEXA · 2022 to 2024
$690k
Defining the developmental mechanisms of pericardium formationF31HL167580 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MORAN, HANNAH ROSE · 2023 to 2024
$65k
NHGRI NIH HHS DP2 HG010013NHGRI NIH HHS R01 HG003988NHLBI NIH HHS F31 HL167580NHLBI NIH HHS R01 HL162304NIDCR NIH HHS R01 DE024745NIDCR NIH HHS R01 DE028599NIDDK NIH HHS R01 DK129350NIGMS NIH HHS T32 GM141742
6 · The paper itself

Abstract

The cell type-specific expression of key transcription factors is central to development. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, and notochord formation; however, how its expression is controlled in the mammalian notochord has remained elusive. Here, we identify the complement of notochord-specific enhancers in the mammalian

Identifiers

PMID37131681
PMCPMC10153258
OpenAlexW4366550858

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.