Evidence map›Paper›PMID 37131678›Full record

ArticlebioRxiv : the preprint server for biology2023

Structure and assembly of a bacterial gasdermin pore.

Alex G Johnson, Megan L Mayer, Stefan L Schaefer, Nora K McNamara-Bordewick, Gerhard Hummer, Philip J Kranzusch

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Alex G JohnsonDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Megan L MayerHarvard Center for Cryo-Electron Microscopy, Harvard Medical School, Boston, MA 02115, USA.
Stefan L SchaeferDepartment of Theoretical Biophysics, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
Nora K McNamara-BordewickDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Gerhard HummerDepartment of Theoretical Biophysics, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
Philip J KranzuschDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Harvard University · USDana-Farber Cancer Institute · USGoethe University Frankfurt · DEMax Planck Institute of Biophysics · DE

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Discovery of cGAS-like signaling enzymes in innate immunity and diseaseDP2GM146250 · NIGMS · DANA-FARBER CANCER INST · PI KRANZUSCH, PHILIP J · 2021 to 2024
$2.5M
NIGMS NIH HHS DP2 GM146250NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

In response to pathogen infection, gasdermin (GSDM) proteins form membrane pores that induce a host cell death process called pyroptosis

Identifiers

PMID37131678
PMCPMC10153256
OpenAlexW4366774856

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.