Evidence map›Paper›PMID 37131659›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial.

Han-Sol Park, Anna Yin, Caelan Barranta, John S Lee, Christopher A Caputo, Jaiprasath Sachithanandham, Maggie Li, Steve Yoon, Ioannis Sitaras, Anne Jedlicka and 71 more

Registry-linked trialOpen access · greenAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04373460 (Comparison of the Efficacy and Safety of Human Coronavirus Immune Plasma), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04373460 phase2completednot on this map

Comparison of the Efficacy and Safety of Human Coronavirus Immune Plasma (HCIP) vs. Control (SARS-CoV-2 Non-immune) Plasma Among Outpatients With Symptomatic COVID-19

TypeinterventionalSponsorJohns Hopkins UniversityRan2020 to 2022Enrolled1,225ConditionsSARS-CoV 2ArmsSARS-CoV-2 convalescent plasma, Plasma from a volunteer donor
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

81 authors at 20 institutions in 1 country.

Han-Sol ParkW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Anna YinW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Caelan BarrantaW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
John S LeeW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Christopher A CaputoW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jaiprasath SachithanandhamW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Maggie LiW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Steve YoonW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Ioannis SitarasW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Anne JedlickaW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Yolanda EbyDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Malathi RamDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Reinaldo E FernandezDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Owen R BakerDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Aarthi G ShenoyDepartment of Medicine, Division of Hematology and Oncology, MedStar Washington Hospital Center, Washington DC, USA.
Giselle S MosnaimDivision of Allergy and Immunology, Department of Medicine, NorthShore University Health System, Evanston, IL, USA.
Yuriko FukutaDepartment of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA.
Bela PatelDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center, Houston, TX, USA.
Sonya L HeathDepartment of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.
Adam C LevineDepartment of Emergency Medicine, Rhode Island Hospital, Brown University, Providence, RI, USA.
Barry R MeisenbergLuminis Health, Annapolis, MD, USA.
Emily S SpivakDepartment of Medicine, Division of Infectious Diseases, University of Utah School of Medicine, Salt Lake City, UT, USA.
Shweta AnjanDepartment of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL, USA.
Moises A HuamanDepartment of Medicine, Division of Infectious Diseases, University of Cincinnati, Cincinnati, OH, USA.
Janis E BlairDepartment of Medicine, Division of Infectious Diseases, Mayo Clinic Hospital, Phoenix, AZ, USA.
Judith S CurrierDepartment of Medicine, Division of Infectious Diseases, University of California, Los Angeles, CA, USA.
James H PaxtonDepartment of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
Jonathan M GerberDepartment of Medicine, Division of Hematology and Oncology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Joann R PetriniNuvance Health, Danbury, CT, USA.
Patrick B BroderickNuvance Health Danbury Hospital, Danbury, CT, USA.
William RauschNuvance Health, Danbury, CT, USA.
Marie Elena CordiscoNuvance Health, Danbury, CT, USA.
Jean HammelNuvance Health Norwalk Hospital, Norwalk, CT, USA.
Benjamin GreenblattNuvance Health Norwalk Hospital, Norwalk, CT, USA.
Valerie C CluzetNuvance Health Vassar Brothers Medical Center, Poughkeepsie, NY, USA.
Daniel CruserNuvance Health Vassar Brothers Medical Center, Poughkeepsie, NY, USA.
Kevin OeiAscada Research, Fullerton, CA, USA.
Matthew AbinanteAscada Research, Fullerton, CA, USA.
Laura L HammittDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0001-6051-1484
Catherine G SutcliffeDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Donald N ForthalDepartment of Medicine, Division of Infectious Diseases, University of California, Irvine, CA, USA.
Martin S ZandDepartment of Medicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-7095-8682
Edward R CachayDepartment of Medicine, Division of Infectious Diseases, University of California, San Diego, CA, USA.
Jay S RavalDepartment of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Seble G KassayeDepartment of Medicine, Division of Infectious Diseases, Georgetown University Medical Center Washington DC, USA.
Christi E MarshallDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anusha YaravaDepartment of Neurology, Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Karen LaneDepartment of Neurology, Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nichol A McBeeDepartment of Neurology, Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Amy L GawadDepartment of Neurology, Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nicky KarlenDepartment of Neurology, Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Atika SinghDepartment of Neurology, Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Daniel E FordInstitute for Clinical and Translational Research Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Douglas A JabsDepartment of Ophthalmology Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lawrence J AppelWelch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
David M ShadeDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Bryan LauDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Stephan EhrhardtDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Sheriza N BakshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Janna R ShapiroW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jiangda OuDepartment of Neurology, Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yu Bin NaDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Maria D KnollDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Elysse Ornelas-GatdulaChemistry-Biology Interface Program, Zanvyl Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore MD, USA.
Netzahualcoyotl Arroyo-CurrasChemistry-Biology Interface Program, Zanvyl Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore MD, USA.
Thomas J GniadekDepartment of Pathology and Laboratory Medicine, Northshore University Health System, Evanston, IL.
Patrizio CaturegliDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jinke WuAdvanced Mammalian Biomanufacturing Innovation Center, Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Nelson NdahiroAdvanced Mammalian Biomanufacturing Innovation Center, Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Michael J BetenbaughAdvanced Mammalian Biomanufacturing Innovation Center, Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Alyssa ZimanDepartment of Pathology and Laboratory Medicine, Wing-Kwai and Alice Lee-Tsing Chung Transfusion Service, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Daniel F HanleyDepartment of Neurology, Brain Injury Outcomes, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-9536-4258
Arturo CasadevallW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Shmuel ShohamDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Evan M BlochDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kelly A GeboDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Aaron A R TobianDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Oliver LaeyendeckerDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, Baltimore, MD, USA.
Andrew PekoszW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0003-3248-1761
Sabra L KleinW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-0730-5224
David J SullivanW. Harry Feinstone Department of Molecular Microbiology and Immunology; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Johns Hopkins University · USCovance (United States) · USNorthShore University HealthSystem · USNorwalk Hospital · USUniversity of California, Los Angeles · USVassar Brothers Medical Center · USBaylor College of Medicine · USBrown University · USDanbury Hospital · USGeorgetown University · USMayo Clinic Hospital · USMedStar Washington Hospital Center · USNational Institute of Allergy and Infectious Diseases · USThe University of Texas Health Science Center at Houston · USUniversity of Alabama at Birmingham · USUniversity of California, Irvine · USUniversity of California San Diego · USUniversity of Cincinnati · USUniversity of Massachusetts Chan Medical School · USUniversity of Miami · US

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Johns Hopkins-Tufts Trial Innovation Center HEAL Pain ERN SupplementU24TR001609 · NCATS · JOHNS HOPKINS UNIVERSITY · PI HANLEY, DANIEL F · 2016 to 2022
$36.3M
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
CTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9M
Conjugate vaccines for prevention and treatment of cryptococcosis - COVID-19 Revision SupplementR01AI152078 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2020 to 2024
$5.1M
The Malaria Transfusion Risk (MATRix) StudyK23HL151826 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BLOCH, EVAN MARTIN · 2020 to 2024
$882k
NCATS NIH HHS U24 TR001609NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR001414NCATS NIH HHS UM1 TR004409NHLBI NIH HHS K23 HL151826NIAID NIH HHS R01 AI152078
6 · The paper itself

Abstract

backgroundThe COVID-19 convalescent plasma (CCP) viral specific antibody levels that translate into recipient post-transfusion antibody levels sufficient to prevent disease progression is not defined.

methodsThis secondary analysis correlated donor and recipient antibody levels to hospitalization risk among unvaccinated, seronegative CCP recipients within the outpatient, double blind, randomized clinical trial that compared CCP to control plasma. The majority of COVID-19 CCP arm hospitalizations (15/17, 88%) occurred in this unvaccinated, seronegative subgroup. A functional cutoff to delineate recipient high versus low post-transfusion antibody levels was established by two methods: 1) analyzing virus neutralization-equivalent anti-S-RBD IgG responses in donors or 2) receiver operating characteristic (ROC) analysis.

resultsSARS-CoV-2 anti-S-RBD IgG antibody was diluted by a factor of 21.3 into post-transfusion seronegative recipients from matched donor units. Viral specific antibody delivered approximated 1.2 mg. The high antibody recipients transfused early (symptom onset within 5 days) had no hospitalizations. A CCP recipient analysis for antibody thresholds correlated to reduced hospitalizations found a significant association with Fisher's exact test between early and high antibodies versus all other CCP recipients (or control plasma) with antibody cutoffs established by both methods-donor virus neutralization-based cutoff: (0/85; 0% versus 15/276; 5.6%) p=0.03 or ROC based cutoff: (0/94; 0% versus 15/267; 5.4%) p=0.01.

conclusionIn unvaccinated, seronegative CCP recipients, early transfusion of plasma units corresponding to the upper 30% of all study donors reduced outpatient hospitalizations. These high antibody level plasma units, given early, should be reserved for therapeutic use.Trial registration: NCT04373460.

fundingDefense Health Agency and others.

Indexed as

convalescent plasmaCOVID-19hospitalizationoutpatientsrandomized controlled trialviral load

Identifiers

PMID37131659
PMCPMC10153328
OpenAlexW4366598181

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.