Evidence map›Paper›PMID 37131656›Full record

ArticlebioRxiv : the preprint server for biology2023

Mining for a New Class of Fungal Natural Products: The Evolution, Diversity, and Distribution of Isocyanide Synthase Biosynthetic Gene Clusters.

Grant R Nickles, Brandon Oestereicher, Nancy P Keller, Milton T Drott

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Grant R NicklesDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Brandon OestereicherMadison, WI, 53703, USA.
Nancy P KellerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Milton T DrottUSDA-ARS Cereal Disease Lab (CDL), St. Paul, MN 55108, USA.
University of Wisconsin–Madison · USCereal Disease Laboratory · USMadison Group (United States) · US

Funding

Biotechnology Training ProgramT32GM135066 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SCOTT M. COYLE, BRIAN G FOX · 2020 to 2026
$7.0M
Comprehensive analysis of NRPS-derived metabolomes of three Aspergillus speciesR01GM112739 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KELLER, NANCY P · 2015 to 2023
$2.8M
NIGMS NIH HHS R01 GM112739NIGMS NIH HHS T32 GM135066
6 · The paper itself

Abstract

The products of non-canonical isocyanide synthase (ICS) biosynthetic gene clusters (BGCs) have notable bioactivities that mediate pathogenesis, microbial competition, and metal-homeostasis through metal-associated chemistry. We sought to enable research into this class of compounds by characterizing the biosynthetic potential and evolutionary history of these BGCs across the Fungal Kingdom. We developed the first genome-mining pipeline to identify ICS BGCs, locating 3,800 ICS BGCs in 3,300 genomes. Genes in these clusters share promoter motifs and are maintained in contiguous groupings by natural selection. ICS BGCs are not evenly distributed across fungi, with evidence of gene-family expansions in several Ascomycete families. We show that the ICS

Identifiers

PMID37131656
PMCPMC10153163
OpenAlexW4366337798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.