Evidence map›Paper›PMID 37131654›Full record

ArticlebioRxiv : the preprint server for biology2023

Single-cell DNA Methylome and 3D Multi-omic Atlas of the Adult Mouse Brain.

Hanqing Liu, Qiurui Zeng, Jingtian Zhou, Anna Bartlett, Bang-An Wang, Peter Berube, Wei Tian, Mia Kenworthy, Jordan Altshul, Joseph R Nery and 22 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 22 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors at 4 institutions in 1 country.

Hanqing LiuGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Qiurui ZengGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Jingtian ZhouGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Anna BartlettGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Bang-An WangGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Peter BerubeGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Wei TianGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Mia KenworthyGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Jordan AltshulGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Joseph R NeryGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Huaming ChenGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Rosa G CastanonGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Songpeng ZuDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.
Yang Eric LiDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.
Jacinta LuceroComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Julia K OsteenComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Antonio Pinto-DuarteComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Jasper LeeComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Jon RinkComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Silvia ChoComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Nora EmersonComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Michael NunnGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Carolyn O'ConnorFlow Cytometry Core Facility, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Zizhen YaoAllen Institute for Brain Science, Seattle, WA, USA.
Kimberly A SmithAllen Institute for Brain Science, Seattle, WA, USA.
Bosiljka TasicAllen Institute for Brain Science, Seattle, WA, USA.
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA.
Chongyuan LuoDepartment of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA.
Jesse R DixonPeptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Bing RenDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.
M Margarita BehrensComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Joseph R EckerGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Salk Institute for Biological Studies · USAllen Institute for Brain Science · USUniversity of California San Diego · USUniversity of California, Los Angeles · US

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ZENG, HONGKUI · 2017 to 2021
$64.7M
Molecular SignaturesU19MH114831 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI CALLAWAY, EDWARD M, ECKER, JOSEPH R · 2017 to 2021
$24.6M
BD FACSAria Fusion for Flow Cytometry Core FacilityS10OD023689 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2018 to 2018
$530k
NIH HHS S10 OD023689NIMH NIH HHS U19 MH114830NIMH NIH HHS U19 MH114831
6 · The paper itself

Abstract

Cytosine DNA methylation is essential in brain development and has been implicated in various neurological disorders. A comprehensive understanding of DNA methylation diversity across the entire brain in the context of the brain's 3D spatial organization is essential for building a complete molecular atlas of brain cell types and understanding their gene regulatory landscapes. To this end, we employed optimized single-nucleus methylome (snmC-seq3) and multi-omic (snm3C-seq

Identifiers

PMID37131654
PMCPMC10153407
OpenAlexW4366279702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.