Evidence map›Paper›PMID 37131634›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct (

Fabian Niess, Bernhard Strasser, Lukas Hingerl, Eva Niess, Stanislav Motyka, Gilbert Hangel, Martin Krššák, Stephan Gruber, Benjamin Spurny-Dworak, Siegfried Trattnig and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Fabian NiessHigh Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Bernhard StrasserHigh Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Lukas HingerlHigh Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Eva NiessHigh Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Stanislav MotykaHigh Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Gilbert HangelHigh Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Martin KrššákDepartment of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna.
Stephan GruberHigh Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Benjamin Spurny-DworakDepartment of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna.
Siegfried TrattnigHigh Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Thomas SchererDepartment of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna.
Rupert LanzenbergerDepartment of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna.
Wolfgang BognerHigh Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Medical University of Vienna · ATKarl Landsteiner Society · AT

Funding

Novel 10.5 T deuterium-based MRS/I method to measure brain metabolismR01EB031787 · NIBIB · UNIVERSITY OF MINNESOTA · PI Wolfgang Bogner, Malgorzata Marjanska · 2022 to 2026
$2.2M
NIBIB NIH HHS R01 EB031787
6 · The paper itself

Abstract

Introduction: Deuterium metabolic imaging (DMI) and quantitative exchange label turnover (QELT) are novel MR spectroscopy techniques for non-invasive imaging of human brain glucose and neurotransmitter metabolism with high clinical potential. Following oral or intravenous administration of non-ionizing [6,6'- Methods: Five volunteers (4m/1f) were scanned in repeated sessions for 60 min after overnight fasting and 0.8g/kg oral [6,6'- Results: One hour after oral tracer administration regionally averaged deuterium labeled Glx Conclusion: This study demonstrates that indirect detection of deuterium labeled compounds using

Identifiers

PMID37131634
PMCPMC10153308
OpenAlexW4366293486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.