Evidence map›Paper›PMID 37131627›Full record

ArticlebioRxiv : the preprint server for biology2023

Collagen and actin network mediate antiviral immunity against Orsay in C. elegans intestinal cells.

Ying Zhou, Weiwei Zhong, Yizhi Jane Tao

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ying ZhouDepartment of Biosciences, Rice University, MS-605, Houston, Texas, 77005, USA.
Weiwei ZhongDepartment of Biosciences, Rice University, MS-605, Houston, Texas, 77005, USA.
Yizhi Jane TaoDepartment of Biosciences, Rice University, MS-605, Houston, Texas, 77005, USA.
Rice University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
The infection mechanism of the nematode virus OrsayR01AI122356 · NIAID · RICE UNIVERSITY · PI TAO, YIZHI JANE · 2016 to 2020
$1.9M
The molecular basis of Orsay virus entry mediated by the CP-delta head fiberR21AI171624 · NIAID · RICE UNIVERSITY · PI TAO, YIZHI JANE · 2022 to 2023
$420k
NIAID NIH HHS R01 AI122356NIAID NIH HHS R21 AI171624NIH HHS P40 OD010440
6 · The paper itself

Abstract

C. elegans is a free-living nematode that is widely used as a small animal model for studying fundamental biological processes and disease mechanisms. Since the discovery of the Orsay virus in 2011, C. elegans also holds the promise of dissecting virus-host interaction networks and innate antiviral immunity pathways in an intact animal. Orsay primarily targets the worm intestine, causing enlarged intestinal lumen as well as visible changes to infected cells such as liquefaction of cytoplasm and rearrangement of the terminal web. Previous studies of Orsay identified that C. elegans is able to mount antiviral responses by DRH-1/RIG-I mediated RNA interference and Intracellular Pathogen Response, a uridylyltransferase that destabilizes viral RNAs by 3' end uridylation, and ubiquitin protein modifications and turnover. To comprehensively search for novel antiviral pathways in

Identifiers

PMID37131627
PMCPMC10153230
OpenAlexW4366771057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.