Evidence map›Paper›PMID 37131615›Full record

ArticlebioRxiv : the preprint server for biology2023

Computational design of non-porous, pH-responsive antibody nanoparticles.

Erin C Yang, Robby Divine, Marcos C Miranda, Andrew J Borst, Will Sheffler, Jason Z Zhang, Justin Decarreau, Amijai Saragovi, Mohamad Abedi, Nicolas Goldbach and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Erin C YangInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Robby DivineInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Marcos C MirandaInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Andrew J BorstInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Will ShefflerInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Jason Z ZhangInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Justin DecarreauInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Amijai SaragoviInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Mohamad AbediInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Nicolas GoldbachInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Maggie AhlrichsInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Craig DobbinsInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Alexis HandInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Suna ChengInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Mila LambInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Paul M LevineInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Sidney ChanInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Rebecca SkotheimInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Jorge FallasInstitute for Protein Design, University of Washington, Seattle, WA, USA.
George UedaInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Joshua LubnerInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Masaharu SomiyaInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Alena KhmelinskaiaInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Neil P KingInstitute for Protein Design, University of Washington, Seattle, WA, USA.
David BakerInstitute for Protein Design, University of Washington, Seattle, WA, USA.

Funding

CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral DynamicsU54AI170856 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI WALTHER H MOTHES · 2022 to 2026
$34.4M
Designed Vehicles for Blood Brain Barrier TraversalR01AG063845 · NIA · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2019 to 2023
$2.5M
Design of de novo interleukin mimics for targeted immunotherapyR01CA240339 · NCI · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2019 to 2023
$2.1M
NCI NIH HHS R01 CA240339NIAID NIH HHS U54 AI170856NIA NIH HHS R01 AG063845
6 · The paper itself

Abstract

Programming protein nanomaterials to respond to changes in environmental conditions is a current challenge for protein design and important for targeted delivery of biologics. We describe the design of octahedral non-porous nanoparticles with the three symmetry axes (four-fold, three-fold, and two-fold) occupied by three distinct protein homooligomers: a

Identifiers

PMID37131615
PMCPMC10153164

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.