Evidence map›Paper›PMID 37131614›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Severity of Prior COVID-19 Infection is Associated with Postoperative Outcomes Following Major Inpatient Surgery.

Nathaniel B Verhagen, Gopika SenthilKumar, Taylor Jaraczewski, Nicolas K Koerber, Jennifer R Merrill, Madelyn A Flitcroft, Aniko Szabo, Anjishnu Banerjee, Xin Yang, Bradley W Taylor and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Nathaniel B VerhagenDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Gopika SenthilKumarDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Taylor JaraczewskiDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Nicolas K KoerberDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Jennifer R MerrillDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Madelyn A FlitcroftDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Aniko SzaboDepartment of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.
Anjishnu BanerjeeDepartment of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.
Xin YangClinical and Translational Science Institute of Southeastern Wisconsin, Medical College of Wisconsin, Milwaukee, WI.
Bradley W TaylorClinical and Translational Science Institute of Southeastern Wisconsin, Medical College of Wisconsin, Milwaukee, WI.
Carlos E Figueroa CastroDepartment of Medicine, Division of Infectious Diseases, Medical College of Wisconsin, Milwaukee, WI.
Tina W F YenDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Callisia N ClarkeDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Kathryn LauerDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI.
Kurt J PfeiferDepartment of Medicine, Section of Perioperative & Consultative Medicine, Medical College of Wisconsin, Milwaukee, WI.
Jon C GouldDepartment of Surgery, Division of Minimally Invasive and GI Surgery, Medical College of Wisconsin, Milwaukee, WI.
Anai N KothariDepartment of Surgery, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI.
Medical College of Wisconsin · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
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6 · The paper itself

Abstract

Objective: To determine the association between severity of prior history of SARS-CoV-2 infection and postoperative outcomes following major elective inpatient surgery. Summary Background Data: Surgical guidelines instituted early in the COVID-19 pandemic recommended delay in surgery up to 8 weeks following an acute SARS-CoV-2 infection. Given that surgical delay can lead to worse medical outcomes, it is unclear if continuation of such stringent policies is necessary and beneficial for all patients, especially those recovering from asymptomatic or mildly symptomatic COVID-19. Methods: Utilizing the National Covid Cohort Collaborative (N3C), we assessed postoperative outcomes for adults with and without a history of COVID-19 who underwent major elective inpatient surgery between January 2020 and February 2023. COVID-19 severity and time from SARS-CoV-2 infection to surgery were each used as independent variables in multivariable logistic regression models. Results: This study included 387,030 patients, of which 37,354 (9.7%) had a diagnosis of preoperative COVID-19. History of COVID-19 was found to be an independent risk factor for adverse postoperative outcomes even after a 12-week delay for patients with moderate and severe SARS-CoV-2 infection. Patients with mild COVID-19 did not have an increased risk of adverse postoperative outcomes at any time point. Vaccination decreased the odds of mortality and other complications. Conclusions: Impact of COVID-19 on postoperative outcomes is dependent on severity of illness, with only moderate and severe disease leading to higher risk of adverse outcomes. Existing wait time policies should be updated to include consideration of COVID-19 disease severity and vaccination status.

Identifiers

PMID37131614
PMCPMC10153306
OpenAlexW4366290787

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.