Vitreoretinal lymphoma presenting as frosted branch angiitis in a patient with diffuse large B-cell lymphoma.

Tomas Andersen, Charles G Miller, Tian Xia, Jose S Pulido, Alexander J Brucker, Albert M Maguire

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In one paragraph

Article in American journal of ophthalmology case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 46% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Vitreoretinal lymphoma presenting as amaurosis fugax.American journal of ophthalmology case reports · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tomas AndersenDepartment of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.

Charles G MillerDepartment of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.

Tian XiaDepartment of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.

Jose S PulidoDepartment of Ophthalmology, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

Alexander J BruckerDepartment of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.

Albert M MaguireDepartment of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.

University of Pennsylvania · USPenn Presbyterian Medical Center · USThomas Jefferson University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To describe the evaluation, diagnosis, and treatment of vitreoretinal lymphoma presenting as frosted branch angiitis in a patient with diffuse large B-cell lymphoma (DLBCL). Observations: A 57-year-old woman with a history of non-Hodgkin lymphoma and recent DLBCL relapse presented with frosted branch angiitis that raised suspicion for an infectious retinitis but was found to be vitreoretinal lymphoma. Conclusions and Importance: This case primarily highlights the importance of considering vitreoretinal lymphoma on the differential diagnosis of etiologies of frosted branch angiitis. Despite suspicion for vitreoretinal lymphoma, it is also important to treat empirically for infectious etiologies of retinitis in cases of frosted branch angiitis. In this case where the diagnosis was ultimately vitreoretinal lymphoma, weekly alternating intravitreal injections of methotrexate and rituximab led to improvement in visual acuity and retinal infiltration.

Indexed as

Frosted branch angiitisIntraocular lymphomaIntravitreal chemotherapyOptic neuritisRetinitisVitreoretinal lymphoma

Identifiers

PMID37131529

DOI10.1016/j.ajoc.2023.101838

PMCPMC10149180

OpenAlexW4362474335

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.