ArticleBMC geriatrics2023
Excessive salt intake accelerates the progression of cerebral small vessel disease in older adults.
Article in BMC geriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Impact of High Dietary Salt on Neurovascular and Cognitive Functions.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Article
- Causal Effect of Dietary Patterns on Cerebral Small Vessel Disease: A Mendelian Randomization Study.Food science & nutrition · 2026Article
- Neutrophil stalling does not mediate the increase in tau phosphorylation and the cognitive impairment associated with high salt diet.Cardiovascular research · 2025Article
- Dietary salt, vascular dysfunction, and cognitive impairment.Cardiovascular research · 2025Review
- Healthy dietary intake diminishes the effect of cerebral small vessel disease on cognitive performance in older adults.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is unclear whether excessive salt intake accelerates the progression of cerebral small vessel disease (CSVD). The major objective of this study was to investigate the harmful effect of excessive salt intake on the progression of CSVD in older individuals.
methodsBetween May 2007 and November 2010, 423 community-dwelling individuals aged 60 years and older were recruited from the Shandong area, China. Salt intake was estimated using 24-hour urine collection for 7 consecutive days at baseline. Participants were classified into low, mild, moderate and high groups according to the salt intake estimation. CSVD including white matter hyperintensities (WMHs), lacunes, microbleeds and an enlarged perivascular space (EPVS) were determined using brain magnetic resonance imaging.
resultsDuring an average of five years of follow-up, the WMH volume and WMH-to-intracranial ratio were increased in the four groups. However, the increasing trends in the WMH volume and WMH-to-intracranial ratio were significantly faster in the higher salt intake groups compared with the lower salt intake groups (P
conclusionOur data indicates that excessive salt intake is an important and independent contributor to the progression of CVSD in older adults.
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Registered trials
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