Evidence map›Paper›PMID 37131126›Full record

Trial reportBMC anesthesiology2023

Comparison of the recovery profile of remimazolam with flumazenil and propofol anesthesia for open thyroidectomy.

Ho-Jin Lee, Hyo Bin Lee, Yoon Jung Kim, Hye-Yeon Cho, Won Ho Kim, Jeong-Hwa Seo

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 6 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Article
  17. Observational
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Ho-Jin LeeDepartment of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Hyo Bin LeeDepartment of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Yoon Jung KimDepartment of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Hye-Yeon ChoDepartment of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Won Ho KimDepartment of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Jeong-Hwa SeoDepartment of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea. eong77@snu.ac.kr.
Seoul National University Hospital · KRNew Generation University College · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have consistently reported a slower recovery of consciousness following remimazolam-based total intravenous anesthesia without flumazenil than with propofol. This study aimed to compare the reversal effect of flumazenil on the recovery of consciousness after remimazolam-based total intravenous anesthesia with the propofol recovery profile.

methodsThis prospective, single-blinded, randomized trial included 57 patients undergoing elective open thyroidectomy at a tertiary university hospital. Patients were randomly allocated to receive either remimazolam- or propofol-based total intravenous anesthesia (remimazolam group: 28 patients, propofol group: 29 patients). The primary outcome was the time from the end of general anesthesia to first eye opening (min). The secondary outcomes were the time from the end of the general anesthesia to extubation (min), initial modified Aldrete score measured at the post-anesthesia care unit, length of stay at the post-anesthesia care unit (min), occurrence of postoperative nausea and vomiting during the first 24 h postoperatively, and Korean version of Quality of Recovery-15 score at 24 h postoperatively.

resultsThe remimazolam group showed significantly faster first eye opening time (2.3 [interquartile range, IQR: 1.8-3.3] min vs. 5.0 [IQR: 3.5-7.8] min, median difference:-2.7 [95% confidence interval, CI: -3.7 to -1.5] min, P < 0.001) and extubation time (3.2 [IQR: 2.4-4.2] min vs. 5.7 [IQR: 4.7-8.3] min, median difference: -2.7 [97.5% CI: -5.0 to -1.6] min, P < 0.001). There were no significant differences in other postoperative outcomes.

conclusionsThe planned incorporation of flumazenil with remimazolam-based total intravenous anesthesia provided rapid and reliable recovery of consciousness.

Indexed as

PropofolAnesthesia, IntravenousAnesthetics, IntravenousBenzodiazepinesFlumazenilHumansPostoperative Nausea and VomitingProspective StudiesThyroidectomyAnesthetics, IntravenousBenzodiazepinesFlumazenilPropofolremimazolamBenzodiazepinesDelayed emergence from anesthesiaFlumazenilGeneral anestheticsIntravenous anesthesia

Identifiers

PMID37131126
PMCPMC10152604
OpenAlexW4367834216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.