Evidence map›Paper›PMID 37131035›Full record

SynthesisCanadian journal of anaesthesia = Journal canadien d'anesthesie2023

Ancillary investigations for death determination in infants and children: a systematic review and meta-analysis.

Nicole K McKinnon, Christina Maratta, Lionel S Zuckier, J Gordon Boyd, Michaël Chassé, Laura Hornby, Andreas Kramer, Julie Kromm, Owen T Mooney, Prakash Muthusami and 4 more

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Death by Neurologic Criteria in Neonates Undergoing Extracorporeal Membrane Oxygenation: Extracorporeal Life Support Organization Registry Study, 2010-2023.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026
    Article
  2. Article
  3. Article
  4. Ancillary tests for brain death.Frontiers in neurology · 2024
    Review
  5. Answering global challenges to the determination of death: consensus-building leadership from Canada.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Nicole K McKinnonDepartment of Critical Care, The Hospital for Sick Children (SickKids), 555 University Avenue, Toronto, ON, M5G 1X8, Canada. nicole.mckinnon@sickkids.ca.ORCID http://orcid.org/0000-0002-7177-1924
Christina MarattaDepartment of Critical Care, The Hospital for Sick Children (SickKids), 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
Lionel S ZuckierDivision of Nuclear Medicine, The Ottawa Hospital, Ottawa, ON, Canada.
J Gordon BoydDepartments of Medicine (Neurology) and Critical Care Medicine, Kingston General Hospital, Kingston, ON, Canada.
Michaël ChasséDepartment of Medicine, Université de Montréal, Montreal, QC, Canada.
Laura HornbyCanadian Blood Services, Ottawa, ON, Canada.
Andreas KramerDepartments of Critical Care Medicine and Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
Julie KrommDepartments of Critical Care Medicine and Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
Owen T MooneySection of Critical Care, Department of Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Prakash MuthusamiDepartment of Diagnostic Imaging, Hospital for Sick Children (SickKids), Toronto, ON, Canada.
Roy NitulescuCentre de Recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.
Jaewoo ParkDepartment of Emergency Medicine, University of Manitoba, Winnipeg, MB, Canada.
Marat SlessarevDepartment of Medicine, Western University, London, ON, Canada.
John BasmajiDepartment of Medicine, Western University, London, ON, Canada.
Centre Hospitalier de l’Université de Montréal · CAUniversity of Manitoba · CAUniversity of Toronto · CAWestern University · CAAlberta Health Services · CACanadian Blood Services · CAQueen's University · CASickKids Foundation · CAUniversity of Calgary · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe performed a systematic review and meta-analysis to determine the diagnostic test accuracy of ancillary investigations for declaration of death by neurologic criteria (DNC) in infants and children. SOURCE: We searched MEDLINE, EMBASE, Web of Science, and Cochrane databases from their inception to June 2021 for relevant randomized controlled trials, observational studies, and abstracts published in the last three years. We identified relevant studies using Preferred Reporting Items for Systematic Reviews and Meta-Analysis methodology and a two-stage review. We assessed the risk of bias using the QUADAS-2 tool, and applied Grading of Recommendations Assessment, Development, and Evaluation methodology to determine the certainty of evidence. A fixed-effects model was used to meta-analyze pooled sensitivity and specificity data for each ancillary investigation with at least two studies. PRINCIPAL

findingsThirty-nine eligible manuscripts assessing 18 unique ancillary investigations (n = 866) were identified. The sensitivity and specificity ranged from 0.00 to 1.00 and 0.50 to 1.00, respectively. The quality of evidence was low to very low for all ancillary investigations, with the exception of radionuclide dynamic flow studies for which it was graded as moderate. Radionuclide scintigraphy using the lipophilic radiopharmaceutical

conclusionThe ancillary investigation for DNC in infants and children with the greatest accuracy appears to be radionuclide scintigraphy using HMPAO with or without tomographic imaging; however, the certainty of the evidence is low. Nonimaging modalities performed at the bedside require further investigation. STUDY REGISTRATION: PROSPERO (CRD42021278788); registered 16 October 2021.

Indexed as

BiasChildHumansInfantSensitivity and Specificityancillary testingbrain deathdeath determinationneurologicpediatrics

Identifiers

PMID37131035
PMCPMC10203011
OpenAlexW4367693837

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.