Evidence map›Paper›PMID 37131020›Full record

GuidelineCanadian journal of anaesthesia = Journal canadien d'anesthesie2023

A brain-based definition of death and criteria for its determination after arrest of circulation or neurologic function in Canada: a 2023 clinical practice guideline.

Sam D Shemie, Lindsay C Wilson, Laura Hornby, John Basmaji, Andrew J Baker, Cécile M Bensimon, Jennifer A Chandler, Michaël Chassé, Rosanne Dawson, Sonny Dhanani and 46 more

Registry-linked trialAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07423936 (Multimodal NeurOmonitoring During NormOthermic Regional PerFusion for Organ Donors Determined Dead by CircuLatory Criteria fOllowing Withdrawal of Life Sustaining Measures), which is not on this map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07423936 recruitingnot on this mapstarted 2025, after this paper: background citation

Multimodal NeurOmonitoring During NormOthermic Regional PerFusion for Organ Donors Determined Dead by CircuLatory Criteria fOllowing Withdrawal of Life Sustaining Measures (NONOFLOW): A Proof-of-Concept Study

TypeobservationalSponsorUniversity of British ColumbiaRan2025 to 2028Enrolled30ConditionsOrgan Preservation, Brain Reperfusion or Regain of Brain Function During Normothermic Regional PerfusionArmsNeuromonitoring
3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. A structured analysis of the concept of brain death.Theoretical medicine and bioethics · 2026
    Article
  7. The Code of Practice 2025 and the medicolegal definition of death.Journal of the Intensive Care Society · 2026
    Article
  8. Article
  9. Article
  10. In reply: Hypoxic-ischemic spinal cord injury after cardiac arrest.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Review
  17. Review
  18. Review
  19. Navigating the gift of life: demystifying the organ donation and transplantation pathway in Canada.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

56 authors.

Sam D ShemieMcGill University Health Centre, 1001 Decarie Blvd, Montreal, QC, H4A 3J1, Canada. sam.shemie@mcgill.ca.ORCID http://orcid.org/0000-0002-9776-1257
Lindsay C WilsonCanadian Blood Services, Ottawa, ON, Canada.
Laura HornbyCanadian Blood Services, Ottawa, ON, Canada.
John BasmajiWestern University, London, ON, Canada.
Andrew J BakerUnity Health Toronto, Toronto, ON, Canada.
Cécile M BensimonCanadian Medical Association, Ottawa, ON, Canada.
Jennifer A ChandlerUniversity of Ottawa, Ottawa, ON, Canada.
Michaël ChasséUniversité de Montréal, Montreal, QC, Canada.
Rosanne DawsonCanadian Blood Services, Ottawa, ON, Canada.
Sonny DhananiUniversity of Ottawa, Ottawa, ON, Canada.
Owen T MooneyUniversity of Manitoba, Winnipeg, MB, Canada.
Aimee J SartiUniversity of Ottawa, Ottawa, ON, Canada.
Christy SimpsonCanadian Blood Services, Ottawa, ON, Canada.
Jeanne TeitelbaumMcGill University Health Centre, 1001 Decarie Blvd, Montreal, QC, H4A 3J1, Canada.
Sylvia Torrance, Ottawa, Canada.
J Gordon BoydKingston General Hospital, Kingston, ON, Canada.
Joanne BrennanThe Ottawa Hospital, Ottawa, ON, Canada.
Heather Brewster, Pilot Mound, Canada.
Robert Carignan, Ponteix, Canada.
Kirk J DaweEastern Health, St. John's, NL, Canada.
Christopher J DoigUniversity of Calgary, Calgary, AB, Canada.
Kennedy Elliott-Pohl, Lethbridge, Canada.
Teneille E GoftonWestern University, London, ON, Canada.
Michael HartwickUniversity of Ottawa, Ottawa, ON, Canada.
Andrew HealeyOntario Health (Trillium Gift of Life Network), Toronto, ON, Canada.
Kimia HonarmandWestern University, London, ON, Canada.
Karen Hornby, Montreal, Canada.
George IsacUniversity of British Columbia, Vancouver, BC, Canada.
Aly KanjiMcGill University Health Centre, 1001 Decarie Blvd, Montreal, QC, H4A 3J1, Canada.
Joann KawchukSaskatchewan Health Authority, Saskatoon, SK, Canada.
Jennifer A KlowakChildren's Hospital of Eastern Ontario, Ottawa, ON, Canada.
Andreas H KramerUniversity of Calgary, Calgary, AB, Canada.
Julie KrommUniversity of Calgary, Calgary, AB, Canada.
Allana E LeBlancUniversity of British Columbia, Vancouver, BC, Canada.
Katarina Lee-AmeduriUniversity of Manitoba, Winnipeg, MB, Canada.
Laurie A LeeUniversity of Calgary, Calgary, AB, Canada.
Murdoch LeeiesUniversity of Manitoba, Winnipeg, MB, Canada.
Ariane LewisNYU Langone Medical Center, New York City, NY, USA.
Alex ManaraNorth Bristol NHS Trust, Bristol, UK.
Shauna MathesonLegacy of Life, Nova Scotia Health, Halifax, NS, Canada.
Nicole K A McKinnonSt. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Nicholas MurphyWestern University, London, ON, Canada.
Joel Neves BriardUniversité de Montréal, Montreal, QC, Canada.
Thaddeus M PopeUniversity of Ottawa, Ottawa, ON, Canada.
Mypinder S SekhonUniversity of British Columbia, Vancouver, BC, Canada.
Jai Jai S ShankerUniversity of Manitoba, Winnipeg, MB, Canada.
Gurmeet SinghMazankowski Alberta Heart Institute, Edmonton, AB, Canada.
Jeffrey SinghSt. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Marat SlessarevWestern University, London, ON, Canada.
Karim SolimanQueen's University, Kingston, ON, Canada.
Stephanie SutherlandThe Ottawa Hospital, Ottawa, ON, Canada.
Matthew J WeissTransplant Québec, Montreal, QC, Canada.
Randi Zlotnik ShaulSt. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Lionel S ZuckierUniversity of Ottawa, Ottawa, ON, Canada.
David J ZorkoSt. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Bram RochwergMcMaster University, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This 2023 Clinical Practice Guideline provides the biomedical definition of death based on permanent cessation of brain function that applies to all persons, as well as recommendations for death determination by circulatory criteria for potential organ donors and death determination by neurologic criteria for all mechanically ventilated patients regardless of organ donation potential. This Guideline is endorsed by the Canadian Critical Care Society, the Canadian Medical Association, the Canadian Association of Critical Care Nurses, Canadian Anesthesiologists' Society, the Canadian Neurological Sciences Federation (representing the Canadian Neurological Society, Canadian Neurosurgical Society, Canadian Society of Clinical Neurophysiologists, Canadian Association of Child Neurology, Canadian Society of Neuroradiology, and Canadian Stroke Consortium), Canadian Blood Services, the Canadian Donation and Transplantation Research Program, the Canadian Association of Emergency Physicians, the Nurse Practitioners Association of Canada, and the Canadian Cardiovascular Critical Care Society.

Indexed as

PhysiciansTissue and Organ ProcurementBrainBrain DeathCanadaChildDeathHumansTissue Donorsbrain deathcirculatory deathdeathdeceased organ donationdefinition of deathneurologic death

Identifiers

PMID37131020
PMCPMC10203028

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.