ReviewTranslational psychiatry2023
Associations of stress and stress-related psychiatric disorders with GrimAge acceleration: review and suggestions for future work.
Review in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Work stress and healthy aging: A conceptual framework for the Semmelweis study and the Semmelweis-EUniWell workplace health promotion model program.GeroScience · 2026Review
- Neighborhood disadvantage and accelerated epigenetic aging in the early aftermath of trauma: The moderating role of individual psychological resources.Journal of psychiatric research · 2026Article
- Epigenetic Aging and Cognitive Performance in General and Psychiatric Populations: A Systematic Review and Narrative Synthesis.Biological psychiatry global open science · 2026Review
- Lifestyle factors and DNA methylation-based aging clocks: cross-sectional and longitudinal associations in the Singapore diet and healthy aging cohort.The journal of prevention of Alzheimer's disease · 2026Article
- Unraveling the causal association of epigenetic age acceleration with common oral diseases and its underlying mechanisms: findings from Mendelian randomization and integrative genetic analysis.Clinical epigenetics · 2025Article
- Lifetime trauma exposure and accelerated epigenetic aging among midlife women.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Work-related stress and burnout: Is epigenetic aging the missing link?Clinical epigenetics · 2025Article
- Cumulative psychosocial factors and epigenetic age acceleration in the Hispanic Community Health Study/Study of Latinos.Epigenomics · 2025Article
- Quantification of Epigenetic Aging in Public Health.Annual review of public health · 2025Review
- EpiAge: a next-generation sequencing-basedAging · 2025Article
- Epigenome-wide association study of placental co-methylated regions in newborns for prenatal opioid exposure.Environmental epigenetics · 2025Article
- No association of posttraumatic stress disorder with epigenetic aging in women at mid-life: A longitudinal cohort study.Brain, behavior, and immunity · 2025Article
- Investigating shared risk variants and genetic etiology between Alzheimer's disease and three stress-related psychiatric disorders: a large-scale genome-wide cross-trait analysis.Frontiers in aging · 2025Article
- Psychosocial Disadvantage During Childhood and Midlife Health: NIMHD Social Epigenomics Program.JAMA network open · 2024Article
- Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology With Geriatric Mental Health Research.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Review
- Methylation ofFrontiers in genetics · 2024Article
- Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The notion of "biological aging" as distinct from chronological aging has been of increasing interest in psychiatry, and many studies have explored associations of stress and psychiatric illness with accelerated biological aging. The "epigenetic clocks" are one avenue of this research, wherein "biological age" is estimated using DNA methylation data from specific CpG dinucleotide sites within the human genome. Many iterations of the epigenetic clocks have been developed, but the GrimAge clock continues to stand out for its ability to predict morbidity and mortality. Several studies have now explored associations of stress, PTSD, and MDD with GrimAge acceleration (GrimAA). While stress, PTSD, and MDD are distinct psychiatric entities, they may share common mechanisms underlying accelerated biological aging. Yet, no one has offered a review of the evidence on associations of stress and stress-related psychopathology with GrimAA. In this review, we identify nine publications on associations of stress, PTSD, and MDD with GrimAA. We find that results are mixed both within and across each of these exposures. However, we also find that analytic methods - and specifically, the choice of covariates - vary widely between studies. To address this, we draw upon popular methods from the field of clinical epidemiology to offer (1) a systematic framework for covariate selection, and (2) an approach to results reporting that facilitates analytic consensus. Although covariate selection will differ by the research question, we encourage researchers to consider adjustment for tobacco, alcohol use, physical activity, race, sex, adult socioeconomic status, medical comorbidity, and blood cell composition.
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