Evidence map›Paper›PMID 37130880›Full record

ArticleNature communications2023

State-level macro-economic factors moderate the association of low income with brain structure and mental health in U.S. children.

David G Weissman, Mark L Hatzenbuehler, Mina Cikara, Deanna M Barch, Katie A McLaughlin

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. White matter reflects the childhood exposome.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  8. Article
  9. The effect of the "exposome" on developmental brain health and cognitive outcomes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  10. Considerations When Accounting for Race and Ethnicity in Studies of Poverty and Neurodevelopment.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Article
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Human development, inequality, and their associations with brain structure across 29 countries.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David G WeissmanDepartment of Psychology, Harvard University, Cambridge, MA, USA. dweissman@fas.harvard.edu.ORCID 0000-0001-9966-3338
Mark L HatzenbuehlerDepartment of Psychology, Harvard University, Cambridge, MA, USA.
Mina CikaraDepartment of Psychology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-6612-4474
Deanna M BarchDepartment of Psychological & Brain Sciences, Washington University, St. Louis, MO, USA.ORCID 0000-0003-1693-8506
Katie A McLaughlinDepartment of Psychology, Harvard University, Cambridge, MA, USA.

Funding

Neurodevelopmental Mechanisms Underlying Stress Vulnerability during AdolescenceR37MH119194 · NIMH · HARVARD UNIVERSITY · PI Katie McLaughlin · 2020 to 2026
$10.6M
Child Trauma and the Development of Neural Systems Underlying Emotion RegulationR01MH103291 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2014 to 2018
$3.8M
Deprivation and Threat: Dimensions of Early Experience and Neural DevelopmentR01MH106482 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2016 to 2020
$3.1M
Neurodevelopmental Mechanisms Underlying Stress Vulnerability during AdolescenceR56MH119194 · NIMH · HARVARD UNIVERSITY · PI MCLAUGHLIN, KATIE · 2019 to 2019
$1.5M
Emotional Awareness: An integrative neural mechanism linking childhood trauma with psychopathologyK99MH127248 · NIMH · HARVARD UNIVERSITY · PI WEISSMAN, DAVID G · 2022 to 2023
$246k
NIMH NIH HHS K99 MH127248NIMH NIH HHS R01 MH103291NIMH NIH HHS R01 MH106482NIMH NIH HHS R37 MH119194NIMH NIH HHS R56 MH119194
6 · The paper itself

Abstract

Macrostructural characteristics, such as cost of living and state-level anti-poverty programs relate to the magnitude of socioeconomic disparities in brain development and mental health. In this study we leveraged data from the Adolescent Brain and Cognitive Development (ABCD) study from 10,633 9-11 year old youth (5115 female) across 17 states. Lower income was associated with smaller hippocampal volume and higher internalizing psychopathology. These associations were stronger in states with higher cost of living. However, in high cost of living states that provide more generous cash benefits for low-income families, socioeconomic disparities in hippocampal volume were reduced by 34%, such that the association of family income with hippocampal volume resembled that in the lowest cost of living states. We observed similar patterns for internalizing psychopathology. State-level anti-poverty programs and cost of living may be confounded with other factors related to neurodevelopment and mental health. However, the patterns were robust to controls for numerous state-level social, economic, and political characteristics. These findings suggest that state-level macrostructural characteristics, including the generosity of anti-poverty policies, are potentially relevant for addressing the relationship of low income with brain development and mental health.

Indexed as

Mental HealthPovertyAdolescentBrainChildEconomic FactorsFemaleHumansIncomeUnited States

Identifiers

PMID37130880
PMCPMC10154403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.