Evidence map›Paper›PMID 37130672›Full record

ArticleBMJ open2023

Effect and safety of C7 neurotomy at the intervertebral foramen in patients with chronic poststroke aphasia: a multicentre, randomised, controlled study protocol.

Tie Li, Juntao Feng, Ruiping Hu, Minzhi Lv, Wenshuo Chang, Xingyi Ma, Wenjun Qi, Ying Zhang, Xiuen Chen, Ling Ding and 2 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Tie LiDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Juntao FengDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Ruiping HuDepartment of Rehabilitation, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Minzhi LvCenter of Evidence-Based Medicine, Department of Biostatistics, School of Public Health, Fudan University, Shanghai, People's Republic of China.
Wenshuo ChangInstitute of Linguistics, Shanghai International Studies University, Shanghai, People's Republic of China.
Xingyi MaDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Wenjun QiDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Ying ZhangDepartment of Rehabilitation, Shanghai Xuhui Central Hospital, Shanghai, People's Republic of China.ORCID 0000-0001-9859-6698
Xiuen ChenDepartment of Rehabilitation, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
Ling DingDepartment of Rehabilitation, Shanghai Pudong Hospital, Shanghai, People's Republic of China.
Yudong GuDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Wendong XuDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China wendongxu@fudan.edu.cn.ORCID 0000-0002-3085-5806
Fudan University · CNPudong Medical Center · CNShanghai International Studies University · CNShanghai Xuhui Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAphasia affects many stroke survivors; therefore, effective treatments are urgently needed. Preliminary clinical findings have suggested an association between contralateral C7-C7 cross nerve transfer and recovery from chronic aphasia. Randomised controlled trials supporting the efficacy of C7 neurotomy (NC7) are lacking. This study will explore the efficacy of NC7 at the intervertebral foramen for improving chronic poststroke aphasia. METHODS AND ANALYSIS: This study protocol reports a multicentre, randomised, assessor-blinded active-controlled trial. A total of 50 patients with chronic poststroke aphasia for over 1 year and with a aphasia quotient calculated by Western Aphasia Battery Aphasia Quotient (WAB-AQ) score below 93.8 will be recruited. Participants will be randomly assigned to 1 of 2 groups (25 individuals each) to receive NC7 plus intensive speech and language therapy (iSLT), or iSLT alone programme. The primary outcome is the change in Boston Naming Test score from baseline to the first follow-up after NC7 plus 3 weeks of iSLT or iSLT alone. The secondary outcomes include the changes in the WAB-AQ, Communication Activities of Daily Living-3, International Classification of Functioning, Disability and Health (ICF) speech language function, Barthel Index, Stroke Aphasic Depression Questionnaire-hospital version and sensorimotor assessments. The study will also collect functional imaging outcomes of naming and semantic violation tasks through functional MRI and electroencephalogram to evaluate the intervention-induced neuroplasticity. ETHICS AND DISSEMINATION: This study was approved by the institutional review boards of Huashan Hospital, Fudan University, and all participating institutions. The study findings will be disseminated through peer-reviewed publications and conference presentations. TRIAL REGISTRATION NUMBER: ChiCTR2200057180.

Indexed as

AphasiaStrokeStroke RehabilitationActivities of Daily LivingHumansMulticenter Studies as TopicRandomized Controlled Trials as TopicSpeech TherapyTreatment OutcomeClinical trialsNeurosurgeryStroke

Identifiers

PMID37130672
PMCPMC10163524
OpenAlexW4367692493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.