Evidence map›Paper›PMID 37130657›Full record

Trial reportOpen heart2023

Randomised trial of stable chest pain investigation: 3-year clinical and quality of life results from CE-MARC 2.

Colin C Everett, Colin Berry, Gerry P McCann, Catherine Fernandez, Catherine Reynolds, Chiara Bucciarelli-Ducci, Erica Dall'Armellina, Abhiram Prasad, James R Foley, Kenneth Mangion and 7 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Open heart, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01664858 (Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease - 2), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01664858 nacompletednot on this map

Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease - 2 (CE-MARC2)

TypeinterventionalSponsorUniversity of LeedsRan2012 to 2018Enrolled1,202ConditionsCoronary Heart DiseaseArms3T CMR, SPECT, CT calcium score, CT coronary angiography, X-Ray coronary angiography
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Colin C EverettSchool of Medicine, University of Leeds, Leeds, UK.
Colin BerryInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Gerry P McCannDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.ORCID 0000-0002-5542-8448
Catherine FernandezSchool of Medicine, University of Leeds, Leeds, UK.
Catherine ReynoldsSchool of Medicine, University of Leeds, Leeds, UK.
Chiara Bucciarelli-DucciDepartment of Cardiology, Harefield Hospital, Harefield, UK.
Erica Dall'ArmellinaSchool of Medicine, University of Leeds, Leeds, UK.
Abhiram PrasadCardiovascular Diseases, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
James R FoleySchool of Medicine, University of Leeds, Leeds, UK.
Kenneth MangionInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Petra BijsterveldSchool of Medicine, University of Leeds, Leeds, UK.
Julia BrownSchool of Medicine, University of Leeds, Leeds, UK.
Deborah StockenSchool of Medicine, University of Leeds, Leeds, UK.
Simon WalkerCentre for Health Economics, University of York, York, UK.ORCID 0000-0002-5750-3691
Mark SculpherCentre for Health Economics, University of York, York, UK.
Sven PleinSchool of Medicine, University of Leeds, Leeds, UK.
John P GreenwoodSchool of Medicine, University of Leeds, Leeds, UK j.greenwood@leeds.ac.uk.ORCID 0000-0002-2861-0914
University of Leeds · GBUniversity of Glasgow · GBUniversity of York · GBHarefield Hospital · GBMayo Clinic · USUniversity of Leicester · GB

Funding

British Heart Foundation FS/13/71/30378British Heart Foundation FS/15/54/31639British Heart Foundation RE/18/6134217British Heart Foundation SP/12/1/29062
6 · The paper itself

Abstract

aimsGuidelines for suspected cardiac chest pain have used historical risk stratification tools, advocating invasive coronary angiography (ICA) first-line in those at highest risk. We aimed to determine whether different strategies to manage suspected stable angina affected medium-term cardiovascular event rates and patient-reported quality of life (QoL) measures.

methodsCE-MARC 2, a three-arm parallel group trial, randomised patients with suspected stable cardiac chest pain and a Duke Clinical pretest likelihood of coronary artery disease between 10% and 90%. Patients were randomised to either first-line cardiovascular magnetic resonance (CMR), single-photon emission computed tomography (SPECT) or the UK National Institute for Health and Care Excellence (NICE) CG95 (2010) guidelines-directed care. For the three arms, 1-year and 3-year first major adverse cardiovascular event (MACE) rates and QoL assessed by the Seattle Angina Questionnaire, Short Form 12 (V.12) Questionnaire and EuroQol-5 Dimension Questionnaire were recorded.

results1202 patients were randomised to CMR (n=481), SPECT (n=481) and NICE (n=240). Forty-two patients (18 CMR, 18 SPECT, 6 NICE) experienced one or more MACEs. The percentage rates (95% CIs) of MACE in the CMR, SPECT and NICE groups at 3 years were 3.7% (2.4%, 5.8%), 3.7% (2.4%, 5.8%) and 2.1% (0.9%, 4.8%), respectively. QoL scores did not significantly differ across domains.

conclusionDespite a fourfold increase in referrals for ICA, the NICE CG95 (2010) guidelines risk-stratified care strategy did not significantly reduce 3-year MACE or improve QoL, as compared with functional imaging with CMR or SPECT. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Registry (NCT01664858).

Indexed as

Angina, StableCoronary Artery DiseaseChest PainCoronary AngiographyHumansQuality of LifeAngina PectorisChest PainCoronary Artery DiseaseMagnetic Resonance ImagingTomography, Emission-Computed, Single-Photon

Identifiers

PMID37130657
PMCPMC10163591
OpenAlexW4367692644

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.