ArticleCell host & microbe2023
Association of distinct microbial signatures with premalignant colorectal adenomas.
Article in Cell host & microbe, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Systematic Review: The Relationship Between the Faecal Microbiome and Colorectal Neoplasia in Shotgun Metagenomic Studies.Alimentary pharmacology & therapeutics · 2025Pooled it
- Spatial mapping of human colonic niches reveals rapid, mucus-specific microbiota disruption after bowel cleansing.Gut microbes · 2026Article
- Observational
- A joint mixture Tobit method with latent microbial abundance improves detection of microbiome-disease associations in zero-inflated data.PLoS computational biology · 2026Article
- Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Prevalence of intestinal spirochaetosis in serrated polyposis syndrome compared with other colorectal polyp conditions: a case-control study in Japan.BMJ open gastroenterology · 2026Article
- MetaCAT enables reconstruction of high-quality microbial genomes and their association with host traits from metagenomic data.Nature microbiology · 2026Article
- Microbiome signatures for detection of colorectal lesions in population-based FIT screening.Nature communications · 2026Article
- Gut microbiota in health and disease.Molecular biomedicine · 2026Review
- Gut microbiome profiles in Chilean participants with colorectal adenomas: an exploratory 16S rRNA sequencing study.Scientific reports · 2026Article
- Fluorescent Nanosensor for Indole-3-Propionic Acid Detection in Gut Health Monitoring.Advanced healthcare materials · 2026Article
- A review of dietary patterns and the colorectal polyp-to-carcinoma sequence: polyp occurrence, polyp recurrence, and colorectal cancer.Frontiers in nutrition · 2026Review
- Gut Microbial Metabolism in Colorectal Cancer.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Article
- Acromegaly and colorectal cancer risk: emerging roles of the gut microbiota.Frontiers in endocrinology · 2026Review
- Oral and gut microbiota after acromegaly treatment: prospective assessment and insights from machine learning.Pituitary · 2025Article
- Microbiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver.Gut microbes · 2025Article
- The Gut Microbiome in Early-Onset Colorectal Cancer: Distinct Signatures, Targeted Prevention and Therapeutic Strategies.Journal of personalized medicine · 2025Review
- Gut microbiota and breast cancer risk: a Mendelian randomization study stratified by ER status.Discover oncology · 2025Article
- Characteristics of the gut virome in patients with premalignant colorectal adenoma.Journal of translational medicine · 2025Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Environmental exposures are a major risk factor for developing colorectal cancer, and the gut microbiome may serve as an integrator of such environmental risk. To study the microbiome associated with premalignant colon lesions, such as tubular adenomas (TAs) and sessile serrated adenomas (SSAs), we profiled stool samples from 971 participants undergoing colonoscopy and paired these data with dietary and medication history. The microbial signatures associated with either SSA or TA are distinct. SSA associates with multiple microbial antioxidant defense systems, whereas TA associates with a depletion of microbial methanogenesis and mevalonate metabolism. Environmental factors, such as diet and medications, link with the majority of identified microbial species. Mediation analyses found that Flavonifractor plautii and Bacteroides stercoris transmit the protective or carcinogenic effects of these factors to early carcinogenesis. Our findings suggest that the unique dependencies of each premalignant lesion may be exploited therapeutically or through dietary intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.