Evidence map›Paper›PMID 37130035›Full record

ArticleTissue engineering. Part A2023

Genome Engineering of Human Urine-Derived Stem Cells to Express Lactoferrin and Deoxyribonuclease.

Zara Kenigsberg, Richard C Welch, Julie Bejoy, Felisha M Williams, Ruth Ann Veach, Isria Jarrett, Trevor K Thompson, Matthew H Wilson, Lauren E Woodard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part A, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Tracking of Urine-Derived Stem Cells in Mice.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zara KenigsbergDivision of Nephrology and Hypertension, Department of Medicine, Medical Center North MCN S3223, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Richard C WelchDivision of Nephrology and Hypertension, Department of Medicine, Medical Center North MCN S3223, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Julie BejoyDivision of Nephrology and Hypertension, Department of Medicine, Medical Center North MCN S3223, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Felisha M WilliamsDivision of Nephrology and Hypertension, Department of Medicine, Medical Center North MCN S3223, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Ruth Ann VeachDivision of Nephrology and Hypertension, Department of Medicine, Medical Center North MCN S3223, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Isria JarrettDivision of Nephrology and Hypertension, Department of Medicine, Medical Center North MCN S3223, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Trevor K ThompsonDivision of Nephrology and Hypertension, Department of Medicine, Medical Center North MCN S3223, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Matthew H WilsonDivision of Nephrology and Hypertension, Department of Medicine, Medical Center North MCN S3223, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Lauren E WoodardDivision of Nephrology and Hypertension, Department of Medicine, Medical Center North MCN S3223, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-5812-1812

Funding

Vanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRIS, RAYMOND C. · 2017 to 2021
$5.9M
Genome engineering of stem cells for kidney regeneration.I01BX004845 · VA · VETERANS HEALTH ADMINISTRATION · PI WOODARD, LAUREN ELIZABETH · 2020 to 2025
–
BLRD VA I01 BX004845NIDDK NIH HHS P30 DK114809
6 · The paper itself

Abstract

Urine-derived stem cells (USCs) are adult kidney cells that have been isolated from a urine sample and propagated in tissue culture on gelatin-coated plates. Urine is a practical and completely painless source of cells for gene and cell therapy applications. We have isolated, expanded, and optimized transfection of USCs to develop regenerative therapies based on

Indexed as

Acute Kidney InjuryLactoferrinAdultAnimalsCell DifferentiationDeoxyribonucleasesHEK293 CellsHumansStem CellsDeoxyribonucleasesLactoferrinkidneytransfectionurine-derived stem cells

Identifiers

PMID37130035
PMCPMC10354709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.