Evidence map›Paper›PMID 37130034›Full record

ArticleJournal of veterinary internal medicine

ACVIM consensus statement guidelines on diagnosing and distinguishing low-grade neoplastic from inflammatory lymphocytic chronic enteropathies in cats.

Sina Marsilio, Valerie Freiche, Eric Johnson, Chiara Leo, Anton W Langerak, Iain Peters, Mark R Ackermann

Open access · goldAbstract readConsensus Statement
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
18.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 5 countries.

Sina Marsilio *Department of Veterinary Medicine and Epidemiology, UC Davis School of Veterinary Medicine, Davis, California, USA.ORCID https://orcid.org/0000-0002-0693-0669
Valerie Freiche *Ecole Nationale Vétérinaire d'Alfort, CHUVA, Unité de Médecine Interne, Maisons-Alfort, France.ORCID https://orcid.org/0000-0003-2041-078X
Eric JohnsonDepartment of Surgical & Radiological Sciences, UC Davis School of Veterinary Medicine, Davis, California, USA.
Chiara LeoAnicura Istituto Veterinario Novara, Novara, Italy.
Anton W LangerakErasmus MC, University Medical Center, Rotterdam, The Netherlands.
Iain PetersVeterinary Pathology Group (VPG), Exeter, UK.
Mark R AckermannOregon Veterinary Diagnostic Laboratory, Oregon State University, Corvallis, Oregon, USA.
École Nationale Vétérinaire d'Alfort · FRErasmus MC · NLNovamont (Italy) · ITOregon State University · USUniversity of California, Davis · USUniversity of Exeter · GBVeterinary Medical Teaching Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLymphoplasmacytic enteritis (LPE) and low-grade intestinal T cell lymphoma (LGITL) are common diseases in older cats, but their diagnosis and differentiation remain challenging.

objectivesTo summarize the current literature on etiopathogenesis and diagnosis of LPE and LGITL in cats and provide guidance on the differentiation between LPE and LGITL in cats. To provide statements established using evidence-based approaches or where such evidence is lacking, statements based on consensus of experts in the field. ANIMALS: None.

methodsA panel of 6 experts in the field (2 internists, 1 radiologist, 1 anatomic pathologist, 1 clonality expert, 1 oncologist) with the support of a human medical immunologist, was formed to assess and summarize evidence in the peer-reviewed literature and complement it with consensus recommendations.

resultsDespite increasing interest on the topic for clinicians and pathologists, few prospective studies were available, and interpretation of the pertinent literature often was challenging because of the heterogeneity of the cases. Most recommendations by the panel were supported by a moderate or low level of evidence. Several understudied areas were identified, including cellular markers using immunohistochemistry, genomics, and transcriptomic studies. CONCLUSIONS AND CLINICAL IMPORTANCE: To date, no single diagnostic criterion or known biomarker reliably differentiates inflammatory lesions from neoplastic lymphoproliferations in the intestinal tract of cats and a diagnosis currently is established by integrating all available clinical and diagnostic data. Histopathology remains the mainstay to better differentiate LPE from LGITL in cats with chronic enteropathy.

Indexed as

Cat DiseasesEnteritisInflammatory Bowel DiseasesAnimalsCatsHumansLymphocytesProspective Studiesalimentarycatchronic diarrheaendoscopygastrointestinalhistologyimmunohistochemistryinflammatory bowel diseaselymphomalymphoplasmacytic enteritislymphoproliferative disordersT-cell

Identifiers

PMID37130034
PMCPMC10229359
OpenAlexW4367669433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.