Evidence map›Paper›PMID 37129738›Full record

Observational studyJournal of neuro-oncology2023

Treatment of hydrocephalus following posterior fossa tumor resection: a multicenter collaboration from the Hydrocephalus Clinical Research Network.

Michael C Dewan, Albert M Isaacs, Michael J Cools, Aaron Yengo-Kahn, Robert P Naftel, Hailey Jensen, Ron W Reeder, Richard Holubkov, Joseline Haizel-Cobbina, Jay Riva-Cambrin and 21 more

Open access · greenAbstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of neuro-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Complication profile of two surgical techniques, neurosurgical experience, and operative setting for pediatric external ventricular drainage implantation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  3. Article
  4. ETV for fourth ventricle outlet obstruction (FVOO) in the long-term period following pediatric posterior fossa tumor resection.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  5. Article
  6. Subtotal tumor resection as a predictor of post-resection hydrocephalus in pediatric patients with posterior fossa tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 20 institutions in 2 countries.

Michael C DewanDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. michael.dewan@vumc.org.
Albert M IsaacsDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael J CoolsDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Aaron Yengo-KahnDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Robert P NaftelDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Hailey JensenDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Ron W ReederDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Richard HolubkovDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Joseline Haizel-CobbinaVanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA.
Jay Riva-CambrinDepartment of Clinical Neurosciences, University of Calgary, Alberta, Canada.
Ryan J JafraniDepartment of Neurosurgery, St. Louis Children's Hospital, Washington University, St. Louis, MO, USA.
Jonathan A PindrikDivision of Pediatric Neurosurgery, Department of Neurological Surgery, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
Eric M JacksonDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Brendan F JudyDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Elena KurudzaDepartment of Neurosurgery, University of Utah, Salt Lake City, UT, USA.
Ian F PollackDepartment of Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Michael M McdowellDepartment of Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Todd C HankinsonDepartment of Neurosurgery, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Susan StaulcupDepartment of Neurosurgery, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Jason HauptmanDepartment of Neurosurgery, University of Washington, Seattle Children's Hospital, Seattle, WA, USA.
Koko HallDepartment of Neurosurgery, University of Washington, Seattle Children's Hospital, Seattle, WA, USA.
Mandeep S TamberDepartment of Surgery, Division of Neurosurgery, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
Alex CheongDepartment of Surgery, Division of Neurosurgery, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
Nebras M WarsiDivision of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Brandon G RocqueDivision of Pediatric Neurosurgery, Department of Neurosurgery, University of Alabama at Birmingham, Children's of Alabama, Birmingham, AL, USA.
Benjamin W SaccomanoDivision of Pediatric Neurosurgery, Department of Neurosurgery, University of Alabama at Birmingham, Children's of Alabama, Birmingham, AL, USA.
Rita I SnyderDivision of Pediatric Neurosurgery, Department of Neurosurgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA.
Abhaya V KulkarniDivision of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
John R W KestleDepartment of Neurosurgery, University of Utah, Salt Lake City, UT, USA.
John C WellonsDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Hydrocephalus Clinical Research Network
Neurological Surgery · USUniversity of Utah · USVanderbilt University Medical Center · USUniversity of Alabama at Birmingham · USChildren's of Alabama · USBC Children's Hospital · CAChildren's Hospital of Pittsburgh · USTexas Children's Hospital · USJohns Hopkins Medicine · USUniversity of British Columbia · CAUniversity of Toronto · CABaylor College of Medicine · USJohns Hopkins University · USNationwide Children's Hospital · USSeattle University · USSickKids Foundation · CASt. Louis Children's Hospital · USUniversity of Calgary · CAUniversity of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Endoscopic versus Shunt Treatment of Hydrocephalus in InfantsU01NS107486 · NINDS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Richard Holubkov, John Kestle · 2019 to 2026
$9.6M
Hydrocephalus Clinical Research Network: a consortium for pediatric hydrocephalusRC1NS068943 · NINDS · UNIVERSITY OF UTAH · PI KESTLE, JOHN · 2009 to 2010
$995k
NCI NIH HHS P30 CA047904NINDS NIH HHS 1U01NS107486-01A1 ESTHININDS NIH HHS RC1 NS068943NINDS NIH HHS U01 NS107486
6 · The paper itself

Abstract

objectivePersistent hydrocephalus following posterior fossa brain tumor (PFBT) resection is a common cause of morbidity in pediatric brain tumor patients, for which the optimal treatment is debated. The purpose of this study was to compare treatment outcomes between VPS and ETV in patients with persistent hydrocephalus following surgical resection of a PFBT.

methodsA post-hoc analysis was performed of the Hydrocephalus Clinical Research Network (HCRN) prospective observational study evaluating VPS and ETV for pediatric patients. Children who experienced hydrocephalus secondary to PFBT from 2008 to 2021 were included. Primary outcomes were VPS/ETV treatment failure and time-to-failure (TTF).

resultsAmong 241 patients, the VPS (183) and ETV (58) groups were similar in age, extent of tumor resection, and preoperative ETV Success Score. There was no difference in overall treatment failure between VPS and ETV (33.9% vs 31.0%, p = 0.751). However, mean TTF was shorter for ETV than VPS (0.45 years vs 1.30 years, p = 0.001). While major complication profiles were similar, compared to VPS, ETV patients had relatively higher incidence of minor CSF leak (10.3% vs. 1.1%, p = 0.003) and pseudomeningocele (12.1% vs 3.3%, p = 0.02). No ETV failures were identified beyond 3 years, while shunt failures occurred beyond 5 years. Shunt infections occurred in 5.5% of the VPS cohort.

conclusionsETV and VPS offer similar overall success rates for PFBT-related postoperative hydrocephalus. ETV failure occurs earlier, while susceptibility to VPS failure persists beyond 5 years. Tumor histology and grade may be considered when selecting the optimal means of CSF diversion.

Indexed as

HydrocephalusInfratentorial NeoplasmsNeuroendoscopyChildHumansRetrospective StudiesTreatment OutcomeVentriculoperitoneal ShuntVentriculostomyEndoscopic third ventriculostomyHydrocephalusPosterior fossa tumorVentriculoperitoneal shunt

Identifiers

PMID37129738
PMCPMC11225566
OpenAlexW4367668603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.