Evidence map›Paper›PMID 37129730›Full record

ArticleStem cell reviews and reports2023

Differentiated Embryonic Neurospheres from Familial Alzheimer's Disease Model Show Innate Immune and Glial Cell Responses.

Micheli Mainardi Pillat, Ana Carolina Ayupe, Guilherme Juvenal, Carine Meinerz, Talita Glaser, Diogo Vieira da Silva Pellegrina, Daisylea Souza Paiva, Carlos Fernando Mello, Beatriz Monteiro Longo, Eduardo Moraes Reis and 1 more

Open access · greenAbstract read
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In one paragraph

Article in Stem cell reviews and reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Micheli Mainardi PillatDepartment of Microbiology and Parasitology, Health Sciences Center, Federal University of Santa Maria, Santa Maria, RS, Brazil. micheli.pillat@ufsm.br.ORCID 0000-0002-6753-6083
Ana Carolina AyupeDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil.ORCID 0000-0001-8062-2659
Guilherme JuvenalDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil.ORCID 0000-0001-9317-9713
Carine MeinerzDepartment of Microbiology and Parasitology, Health Sciences Center, Federal University of Santa Maria, Santa Maria, RS, Brazil.ORCID 0000-0002-2185-6305
Talita GlaserDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil.ORCID 0000-0002-3350-4569
Diogo Vieira da Silva PellegrinaInterunit Graduate Program in Bioinformatics, University of São Paulo, Sao Paulo, SP, Brazil.ORCID 0000-0001-6423-5093
Daisylea Souza PaivaDepartment of Physiology, Federal University of São Paulo, São Paulo, SP, Brazil.ORCID 0000-0002-2329-8810
Carlos Fernando MelloDepartment of Microbiology and Parasitology, Health Sciences Center, Federal University of Santa Maria, Santa Maria, RS, Brazil.ORCID 0000-0002-1326-1045
Beatriz Monteiro LongoDepartment of Physiology, Federal University of São Paulo, São Paulo, SP, Brazil.ORCID 0000-0002-2638-8061
Eduardo Moraes ReisDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil.ORCID 0000-0002-9556-3070
Henning UlrichDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil. henning@iq.usp.br.ORCID 0000-0002-2114-3815
Universidade de São Paulo · BRUniversidade Federal de Santa Maria · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteins involved in the Alzheimer's disease (AD), such as amyloid precursor protein (APP) and presenilin-1 (PS1), play critical roles in early development of the central nervous system (CNS), as well as in innate immune and glial cell responses. Familial AD is associated with the presence of APP

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsCell DifferentiationImmunity, InnateInflammation MediatorsLeukocytes, MononuclearMiceMice, TransgenicNeurogliaAmyloid beta-Protein PrecursorInflammation MediatorsCytokinesDegenerative diseaseNeural developmentNeural progenitor cellsNeuroinflammation

Identifiers

PMID37129730
OpenAlexW4367668938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.