Evidence map›Paper›PMID 37129713›Full record

ArticleMedical molecular morphology2023

A case of coexistent poorly differentiated adenosquamous carcinoma (glassy cell carcinoma), usual-type adenocarcinoma, and squamous cell carcinoma in situ of the cervix.

Kouki Habara, Asami Nishikori, Jin Kiyama, Manami Nakashima, Masanori Koda, Kenji Sasaki, Tomohisa Sakashita, Norifumi Tanaka, Shuji Yonehara

Erratum issuedOpen access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical molecular morphology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kouki HabaraDepartment of Pathology, Japan Agricultural Cooperatives Onomichi General Hospital, 1-10-23 Hirahara, Onomichi, Hiroshima, Japan. k_habaramomizi326@outlook.jp.ORCID http://orcid.org/0000-0002-7248-5030
Asami NishikoriDepartment of Molecular Hematopathology, Faculty of Health Sciences, Okayama University School of Medicine, 2-5-1 Shikata, Kita-Ku, Okayama, Japan.
Jin KiyamaDepartment of Medical Technology, Okayama University Hospital, 2-5-1 Shikata, Kita-ku, Okayama, Japan.
Manami NakashimaDepartment of Pathology, Japan Agricultural Cooperatives Onomichi General Hospital, 1-10-23 Hirahara, Onomichi, Hiroshima, Japan.
Masanori KodaDepartment of Pathology, Japan Agricultural Cooperatives Onomichi General Hospital, 1-10-23 Hirahara, Onomichi, Hiroshima, Japan.
Kenji SasakiDepartment of Pathology, Japan Agricultural Cooperatives Onomichi General Hospital, 1-10-23 Hirahara, Onomichi, Hiroshima, Japan.
Tomohisa SakashitaDepartment of Obstetrics and Gynecology, Japan Agricultural Cooperatives Onomichi General Hospital, 1-10-23 Hirahara, Onomichi, Hiroshima, Japan.
Norifumi TanakaDepartment of Obstetrics and Gynecology, National Hospital Organization East Hiroshima Medical Center, 513 Jike, Saijo, Higashihiroshima, Hiroshima, Japan.
Shuji YoneharaDepartment of Pathology, Japan Agricultural Cooperatives Onomichi General Hospital, 1-10-23 Hirahara, Onomichi, Hiroshima, Japan.
Onomichi General Hospital · JPHigashihiroshima Medical Center · JPOkayama University · JPOkayama University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poorly differentiated adenosquamous carcinoma (glassy cell carcinoma) of the cervix is extremely rare, accounting for 1-2% of all cervical cancers. Herein, we report a case with coexistent poorly differentiated adenosquamous carcinoma (glassy cell carcinoma), "usual-type" adenocarcinoma, and squamous cell carcinoma in situ of the cervix. A female patient in her 60 s was referred to our hospital and diagnosed with poorly differentiated adenosquamous carcinoma based on cervical cytology and biopsy. The tumor was classified as clinical stage IB1 cervical cancer following magnetic resonance imaging; radical hysterectomy was performed. Histopathological examination revealed poorly differentiated adenosquamous carcinoma (glassy cell carcinoma), usual-type adenocarcinoma, and squamous cell carcinoma in situ, all coexisting. All carcinoma regions showed identical sizes to high-risk human papillomavirus (HPV) in fragment analysis. The patient is currently alive, without evidence of recurrence, 31 months post surgery. In this case, three different carcinomas coexisted. Fragment analysis of the patient's HPV status suggested that all carcinomas were related to an infection with the same high-risk HPV type. To determine the precise mechanism of tumor development, i.e., whether the tumors were of the mixed or collision type, further studies are needed, including clonal analysis for the loss of heterozygosity pattern.

Indexed as

AdenocarcinomaCarcinoma, AdenosquamousCarcinoma, Squamous CellPapillomavirus InfectionsUterine Cervical NeoplasmsAgedCervix UteriFemaleHumansFragment analysisGlassy cell carcinomaHuman papillomavirusLoss of heterozygositySquamous cell carcinoma in situUsual-type adenocarcinoma

Identifiers

PMID37129713
PMCPMC10415468
OpenAlexW4367669009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.