ArticleKidney international1986
Glomerular filtration surface in type I diabetes mellitus.
Article in Kidney international, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02911792 (Effect of Farxiga on Renal Function and Size in Type 2 Diabetic Patients With Hyperfiltration), which is not on this map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Farxiga on Renal Function and Size in Type 2 Diabetic Patients With Hyperfiltration
Who cites it
45 citing papers in PubMed, 173 citations in OpenAlex.
- The relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes.Diabetologia · 2010Trial
- Trial
- Early glomerulopathy is present in young, type 1 (insulin-dependent) diabetic patients with microalbuminuria.Diabetologia · 1993Trial
- Enalapril does not alter renal function in normotensive, normoalbuminuric, hyperfiltering type 1 (insulin-dependent) diabetic children.Diabetologia · 1989Trial
- Heterogeneity in the relationships between albuminuria and glomerular structure in type 1 and type 2 diabetes.Kidney international · 2026Article
- Capillary rarefaction: a missing link in renal and cardiovascular disease?Angiogenesis · 2024Review
- Comparative evaluation of glomerular morphometric techniques reveals differential technical artifacts between focal segmental glomerulosclerosis and normal glomeruli.Physiological reports · 2023Article
- Retinal Vascular Signs as Screening and Prognostic Factors for Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Current Evidence.Journal of personalized medicine · 2021Review
- The Glomerulus According to the Mesangium.Frontiers in medicine · 2021Review
- Autologous induced pluripotent stem cell-derived four-organ-chip.Future science OA · 2019Article
- Urine inositol pentakisphosphate 2-kinase and changes in kidney structure in early diabetic kidney disease in type 1 diabetes.American journal of physiology. Renal physiology · 2018Article
- Urine metabolites are associated with glomerular lesions in type 2 diabetes.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study.Scientific reports · 2017Article
- Renal glomerular dysfunction in relation to retinal arteriolar narrowing and high pulse pressure in seniors.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes.Clinical journal of the American Society of Nephrology : CJASN · 2016Observational
- Glomerular structural-functional relationship models of diabetic nephropathy are robust in type 1 diabetic patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2015Review
- Podocyte structural parameters do not predict progression to diabetic nephropathy in normoalbuminuric type 1 diabetic patients.American journal of nephrology · 2015Article
- Diabetic kidney disease in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2015Review
- Comprehensive approach to diabetic nephropathy.Kidney research and clinical practice · 2014Review
- Renal lesions predict progression of diabetic nephropathy in type 1 diabetes.Journal of the American Society of Nephrology : JASN · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Previously we have shown that relative glomerular mesangial expansion was an important correlate of renal dysfunction in diabetes. To extend the understanding of structural functional relationships, 37 patients with type I diabetes mellitus for 5 to 33 years were studied with multiple creatinine clearance (Ccr), urinary albumin excretion, and blood pressure measurements, and percutaneous renal biopsies. Glomerular volume and percent sclerosed glomeruli were determined; quantitative stereology was performed to determine relative glomerular structural parameters. Per glomerulus we calculated mesangial volume and capillary filtration surface and per patient we estimated capillary filtration surface. Capillary filtration surface per glomerulus or per patient were highly predictive of Ccr (r = +0.78, r = +0.79, P less than 0.001). There was a significant but weak relationship between Ccr and mesangial volume. However, mesangial volume and glomerular volume together were highly predictive of both Ccr and filtration surface. Mesangial volume was increased and filtration surface decreased in the hypertensive patients and the patients with urinary albumin excretion less than 250 mg/24 hr. Thus, it appears that mesangial expansion within a relatively large glomerulus has less influence on filtration than does a similar increase in mesangial volume within a smaller glomerulus. There is a striking relationship between glomerular filtration rate and filtration surface in diabetes throughout the range from hyperfiltration to significant hypofiltration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.