Evidence map›Paper›PMID 37129526›Full record

ArticleInfection and immunity2023

Invasive Non-Typhoidal

Erin M Vasicek, John S Gunn

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Plasmid encodedBiofilm · 2026
    Article
  3. Autosomal recessiveMolecular genetics and metabolism reports · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Shedding of nontyphoidalJournal of clinical microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Erin M VasicekCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
John S GunnCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0000-0003-2848-8346
Nationwide Children's Hospital · US

Funding

Mechanisms of the Development and Maintenance of Salmonella Gallbladder CarriageR01AI116917 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GUNN, JOHN S, MELANDER, CHRISTIAN COREY · 2015 to 2025
$6.1M
Regulation and role of Salmonella curli during chronic infectionR21AI153752 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GUNN, JOHN S · 2020 to 2021
$424k
Salmonella chronic infection: Biofilm matrix factors and innate immune toleranceR21AI156328 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GUNN, JOHN S · 2021 to 2022
$424k
NIAID NIH HHS R01 AI116917NIAID NIH HHS R21 AI153752NIAID NIH HHS R21 AI156328
6 · The paper itself

Abstract

Non-typhoidal Salmonella (NTS) serovars have a broad host range and cause gastroenteritis in humans. However, invasive NTS (iNTS) bloodstream infections have increased in the last decade, causing 60,000 deaths annually. Human-specific typhoidal Salmonella colonizes and forms biofilms on gallstones, resulting in chronic, asymptomatic infection. iNTS lineages are undergoing genomic reduction and may have adapted to person-to-person transmission via mutations in virulence, bile resistance, and biofilm formation. As such, we sought to determine the capacity of iNTS lineages for biofilm formation and the development of chronic infections in the gallbladder in our mouse model. Of the lineages tested (L1, L2, L3 and UK), only L2 and UK were defective for the rough, dry and red (RDAR) morphotype, correlating with the known

Indexed as

GallbladderTyphoid FeverAnimalsBiofilmsCelluloseHumansMiceMutationSalmonellaCellulosebiofilmsbloodstream infectionschronic infectionsgallbladderinvasive microorganismsSalmonella

Identifiers

PMID37129526
PMCPMC10187132
OpenAlexW4367322370

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.