Evidence map›Paper›PMID 37129520›Full record

ReviewJournal of virology2023

The Intersection of Innate Immune Pathways with the Latent Herpes Simplex Virus Genome.

Sean R Cuddy, Anna R Cliffe

Abstract readReview
In one paragraph

Review in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. The implication of infection with respiratory syncytial virus in pediatric recurrent wheezing and asthma: knowledge expanded post-COVID-19 era.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sean R CuddyNeuroscience Graduate Program, University of Virginia, Charlottesville, Virginia, USA.
Anna R CliffeDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0003-1136-5171

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
Cell stress-mediated changes in the Herpes simplex virus type 1 chromatin structure during reactivation from latent infectionR01NS105630 · NINDS · UNIVERSITY OF VIRGINIA · PI CLIFFE, ANNA RUTH · 2018 to 2022
$1.8M
IFN-dependent repression of HSV latency by PML-nuclear bodiesR21AI151340 · NIAID · UNIVERSITY OF VIRGINIA · PI CLIFFE, ANNA RUTH · 2020 to 2021
$444k
NIAID NIH HHS R21 AI151340NIAID NIH HHS T32 AI007046NINDS NIH HHS R01 NS105630
6 · The paper itself

Abstract

Innate immune responses can impact different stages of viral life cycles. Herpes simplex virus latent infection of neurons and subsequent reactivation provide a unique context for immune responses to intersect with different stages of infection. Here, we discuss recent findings linking neuronal innate immune pathways with the modulation of latent infection, acting at the time of reactivation and during initial neuronal infection to have a long-term impact on the ability of the virus to reactivate.

Indexed as

Herpes SimplexHerpesvirus 1, HumanLatent InfectionGenome, ViralHumansImmunity, InnateVirus ActivationVirus Latencyherpes simplex virusIL-1innate immune memoryinterferonslatent infectionneuronsreactivation

Identifiers

PMID37129520
PMCPMC10231182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.