Evidence map›Paper›PMID 37129493›Full record

ArticleRadiology2023

Prospective Evaluation of PI-RADS Version 2.1 for Prostate Cancer Detection and Investigation of Multiparametric MRI-derived Markers.

Enis C Yilmaz, Joanna H Shih, Mason J Belue, Stephanie A Harmon, Tim E Phelps, Charisse Garcia, Lindsey A Hazen, Antoun Toubaji, Maria J Merino, Sandeep Gurram and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Enis C YilmazFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.ORCID 0000-0001-5301-3137
Joanna H ShihFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.ORCID 0000-0001-9815-3651
Mason J BelueFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.ORCID 0000-0002-1298-9958
Stephanie A HarmonFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.ORCID 0000-0002-2507-2399
Tim E PhelpsFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.
Charisse GarciaFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.
Lindsey A HazenFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.ORCID 0000-0003-4013-8226
Antoun ToubajiFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.
Maria J MerinoFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.
Sandeep GurramFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.
Peter L ChoykeFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.ORCID 0000-0003-1086-8826
Bradford J WoodFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.ORCID 0000-0002-4297-0051
Peter A PintoFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.ORCID 0000-0002-0190-5931
Baris TurkbeyFrom the Molecular Imaging Branch (E.C.Y., M.J.B., S.A.H., T.E.P., P.L.C., B.T.), Biometric Research Program, Division of Cancer Treatment and Diagnosis (J.H.S.), Center for Interventional Oncology (C.G., L.A.H., B.J.W.), Department of Radiology, Clinical Center (C.G., L.A.H., B.J.W.), Laboratory of Pathology (A.T., M.J.M.), and Urologic Oncology Branch (S.G., P.A.P.), National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Building 10, Room B3B85, Bethesda, MD 20892.ORCID 0000-0003-0853-6494
National Institutes of Health · USAnna Needs Neuroblastoma Answers · US

Funding

Clinical Fellowship Training ProgramZIEBC011023 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PINTO, PETER · 2009 to 2025
$10.3M
Navigation Tools for Image Guided Minimally invasive TherapiesZIACL040011 · CLC · CLINICAL CENTER · PI WOOD, BRADFORD · 2009 to 2025
$0k
Interventional OncologyZIACL040015 · CLC · CLINICAL CENTER · PI WOOD, BRADFORD · 2009 to 2025
$0k
6 · The paper itself

Abstract

Background Data regarding the prospective performance of Prostate Imaging Reporting and Data System (PI-RADS) version 2.1 alone and in combination with quantitative MRI features for prostate cancer detection is limited. Purpose To assess lesion-based clinically significant prostate cancer (csPCa) rates in different PI-RADS version 2.1 categories and to identify MRI features that could improve csPCa detection. Materials and Methods This single-center prospective study included men with suspected or known prostate cancer who underwent multiparametric MRI and MRI/US-guided biopsy from April 2019 to December 2021. MRI scans were prospectively evaluated using PI-RADS version 2.1. Atypical transition zone (TZ) nodules were upgraded to category 3 if marked diffusion restriction was present. Lesions with an International Society of Urological Pathology (ISUP) grade of 2 or higher (range, 1-5) were considered csPCa. MRI features, including three-dimensional diameter, relative lesion volume (lesion volume divided by prostate volume), sphericity, and surface to volume ratio (SVR), were obtained from lesion contours delineated by the radiologist. Univariable and multivariable analyses were conducted at the lesion and participant levels to determine features associated with csPCa. Results In total, 454 men (median age, 67 years [IQR, 62-73 years]) with 838 lesions were included. The csPCa rates for lesions categorized as PI-RADS 1 (

Indexed as

Multiparametric Magnetic Resonance ImagingProstatic NeoplasmsAgedHumansImage-Guided BiopsyMagnetic Resonance ImagingMaleProspective StudiesProstateRetrospective Studies

Identifiers

PMID37129493
PMCPMC10323290
OpenAlexW4367668684

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.