Evidence map›Paper›PMID 37129482›Full record

ArticleGlycobiology2023

Bridging glycoinformatics and cheminformatics: integration efforts between GlyCosmos and PubChem.

Tiejun Cheng, Tamiko Ono, Masaaki Shiota, Issaku Yamada, Kiyoko F Aoki-Kinoshita, Evan E Bolton

Open access · hybridAbstract read
In one paragraph

Article in Glycobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Glycoscience data content in the NCBI Glycans and PubChem.Analytical and bioanalytical chemistry · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Tiejun ChengNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, United States.ORCID 0000-0002-4486-3356
Tamiko OnoGlycan and Life Systems Integration Center, Soka University, 1-236 Tangi-machi, Hachioji, Tokyo 192-8577, Japan.
Masaaki ShiotaGlycan and Life Systems Integration Center, Soka University, 1-236 Tangi-machi, Hachioji, Tokyo 192-8577, Japan.
Issaku YamadaLaboratory of Glycoinformatics, The Noguchi Institute, 1-9-7 Kaga, Itabashi, Tokyo 173-0003, Japan.ORCID 0000-0001-9504-189X
Kiyoko F Aoki-KinoshitaGlycan and Life Systems Integration Center, Soka University, 1-236 Tangi-machi, Hachioji, Tokyo 192-8577, Japan.ORCID 0000-0002-6662-8015
Evan E BoltonNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, United States.ORCID 0000-0002-5959-6190
Soka University · JPNational Institutes of Health · USNoguchi Institute · JP

Funding

National Biomedical Information ServicesZIHLM200888 · NLM · NATIONAL LIBRARY OF MEDICINE · PI PALTOO, DINA · 2009 to 2025
$5200.7M
6 · The paper itself

Abstract

The GlyCosmos Glycoscience Portal (https://glycosmos.org) and PubChem (https://pubchem.ncbi.nlm.nih.gov/) are major portals for glycoscience and chemistry, respectively. GlyCosmos is a portal for glycan-related repositories, including GlyTouCan, GlycoPOST, and UniCarb-DR, as well as for glycan-related data resources that have been integrated from a variety of 'omics databases. Glycogenes, glycoproteins, lectins, pathways, and disease information related to glycans are accessible from GlyCosmos. PubChem, on the other hand, is a chemistry-based portal at the National Center for Biotechnology Information. PubChem provides information not only on chemicals, but also genes, proteins, pathways, as well as patents, bioassays, and more, from hundreds of data resources from around the world. In this work, these 2 portals have made substantial efforts to integrate their complementary data to allow users to cross between these 2 domains. In addition to glycan structures, key information, such as glycan-related genes, relevant diseases, glycoproteins, and pathways, was integrated and cross-linked with one another. The interfaces were designed to enable users to easily find, access, download, and reuse data of interest across these resources. Use cases are described illustrating and highlighting the type of content that can be investigated. In total, these integrations provide life science researchers improved awareness and enhanced access to glycan-related information.

Indexed as

Databases, ChemicalPolysaccharidesGlycoconjugatesGlycosylationInformaticsWorkflowGlycoconjugatesPolysaccharidesdatabasesglycoinformaticsintegrationweb portal

Identifiers

PMID37129482
PMCPMC10284107
OpenAlexW4367669627

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.